{"id":"W4387077652","doi":"10.1002/ana.26807","title":"A Genetic Risk Variant for Multiple Sclerosis Severity is Associated with Brain Atrophy","year":2023,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"HORIZON EUROPE European Innovation Council; NIH Clinical Center; Deutsche Forschungsgemeinschaft; Bayerisches Staatsministerium für Bildung und Kultus, Wissenschaft und Kunst; National Institute of Neurological Disorders and Stroke; European Commission","keywords":"Multiple sclerosis; Atrophy; Cohort; Magnetic resonance imaging; Allele; Medicine; Neuroscience; Psychology; Oncology; Internal medicine; Genetics; Biology; Psychiatry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006641943,0.0006228182,0.0004181064,0.0005939235,0.0003727953,0.0004212889,0.0003420869,0.0006740228,0.003417734],"category_scores_gemma":[0.003549954,0.0002195681,0.0006129114,0.000749399,0.0003360026,0.0002273586,0.0003211318,0.0005613851,0.0002747544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001604776,"about_ca_system_score_gemma":0.0001823943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002523545,"about_ca_topic_score_gemma":0.002859297,"domain_scores_codex":[0.999519,0.0001877217,0.00006235282,0.0001348853,0.00006192614,0.00003414708],"domain_scores_gemma":[0.9979504,0.000749001,0.0007846088,0.0002041433,0.000109715,0.0002022489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00387274,0.0001328517,0.9595327,0.00007922445,0.001194515,0.001162698,0.0001934136,0.0001556844,0.02538497,0.000120347,0.0003048693,0.007866091],"study_design_scores_gemma":[0.0001341145,0.0004313618,0.9956136,0.00001772741,0.0003509017,0.001641799,0.00005865784,0.0003127578,0.0008886462,0.0002315661,0.0003080382,0.0000109172],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987645,0.0003858763,0.0002042576,0.0001031448,0.00001040326,0.00000817877,0.0001723034,0.00001078164,0.0003405498],"genre_scores_gemma":[0.999535,0.00005556976,0.0001635919,0.00002759289,0.00001259565,0.000003485955,0.00009446327,0.000003723904,0.0001040276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003417734,"threshold_uncertainty_score":0.01143342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1602278018019726,"score_gpt":0.3447475067279656,"score_spread":0.184519704925993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}