{"id":"W4387081360","doi":"10.2337/db23-0171","title":"IL-6 Trans-Signaling Is Increased in Diabetes, Impacted by Glucolipotoxicity, and Associated With Liver Stiffness and Fibrosis in Fatty Liver Disease","year":2023,"lang":"en","type":"article","venue":"Diabetes","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Institut universitaire de cardiologie et de pneumologie de Québec; Centre Hospitalier de l’Université de Montréal; McGill University; Université Laval; Université de Montréal; Montreal Clinical Research Institute","funders":"International Development Research Centre; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Eli Lilly and Company","keywords":"Endocrinology; Internal medicine; Fatty liver; Hepatic stellate cell; Steatohepatitis; Nonalcoholic fatty liver disease; Diabetes mellitus; Medicine; Liver disease; Fibrosis; Hepatocyte; Biology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001293232,0.0002834933,0.000269015,0.0004107283,0.0001222523,0.0003192846,0.00007984033,0.0002155468,0.00143582],"category_scores_gemma":[0.0002674117,0.0001102231,0.000238261,0.0004143619,0.0001583619,0.0001447036,0.0002422206,0.000406996,0.0001651347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001044095,"about_ca_system_score_gemma":0.00007124569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003855417,"about_ca_topic_score_gemma":0.000428488,"domain_scores_codex":[0.9998893,0.00002091008,0.00001423002,0.00002846886,0.00002965042,0.00001747008],"domain_scores_gemma":[0.999817,0.00001836858,0.00009925462,0.000009309186,0.0000209263,0.00003508489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004992705,0.0001200343,0.707477,0.0003155837,0.0003217816,0.001360117,0.0003184044,0.0001595754,0.252527,0.0001415478,0.000572119,0.03169414],"study_design_scores_gemma":[0.00001383616,0.0001895296,0.9892961,0.00002158363,0.000109084,0.001859271,0.00008941141,0.0002185158,0.007349577,0.0001207837,0.0007258563,0.000006446302],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959249,0.002621331,0.0004786647,0.00009530199,0.00001511742,0.000005097541,0.0003916477,0.00002064952,0.0004471765],"genre_scores_gemma":[0.9980215,0.000853777,0.0003287136,0.00005731602,0.00002729107,0.000006515796,0.0003554384,0.0000043755,0.0003452652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00143582,"threshold_uncertainty_score":0.0048033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01460478225926004,"score_gpt":0.2360301948840069,"score_spread":0.2214254126247469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}