{"id":"W4387088119","doi":"10.2139/ssrn.4581770","title":"Dual Inhibition of Coronavirus M<sup>pro</sup> and PL<sup>pro</sup> Enzymes by Phenothiazines and Their Antiviral Activity","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Saint Vincent University; University of Saskatchewan; Dalhousie University","funders":"","keywords":"Coronavirus; Enzyme; Molecular biology; Virology; Coronavirus disease 2019 (COVID-19); Chemistry; Biology; Biochemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.002379886,0.001760098,0.001975169,0.0004378406,0.0008150226,0.0004701665,0.0007600596,0.001522119,0.0000572436],"category_scores_gemma":[0.0003188801,0.001512847,0.0008351114,0.0003418192,0.0008443752,0.0001529483,0.001380719,0.003024466,0.00001535891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000377382,"about_ca_system_score_gemma":0.002028045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002170857,"about_ca_topic_score_gemma":0.001222845,"domain_scores_codex":[0.9915972,0.0006425112,0.001474179,0.002012165,0.000935631,0.003338294],"domain_scores_gemma":[0.9963607,0.0002465725,0.001451855,0.001054968,0.0004882022,0.0003977329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001383095,0.0008174127,0.001064835,0.0006489095,0.001840785,0.0000315076,0.0007380109,0.00026112,0.9295513,0.003446769,0.00291868,0.05729757],"study_design_scores_gemma":[0.01067698,0.006222065,0.00524051,0.002430098,0.001834017,0.002185992,0.00344226,0.005829773,0.7955865,0.06259833,0.09585485,0.008098684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9519656,0.04166915,0.001865777,0.0009622492,0.0005367766,0.001013183,0.00125637,0.000119521,0.0006114084],"genre_scores_gemma":[0.9452336,0.04859537,0.0001510112,0.0001630933,0.002497151,0.0001446729,0.000587299,0.0002909016,0.002336919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1339649,"threshold_uncertainty_score":0.9997741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01679022086579973,"score_gpt":0.247138893089257,"score_spread":0.2303486722234572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}