{"id":"W4387095473","doi":"10.1016/j.kint.2023.08.025","title":"A novel multi-ancestry proteome-wide Mendelian randomization study implicates extracellular proteins, tubular cells, and fibroblasts in estimated glomerular filtration rate regulation","year":2023,"lang":"en","type":"article","venue":"Kidney International","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; St. Joseph’s Healthcare Hamilton; Impact; McMaster University; Population Health Research Institute","funders":"Servier; Ontario Ministry of Health and Long-Term Care; Kidney Foundation of Canada; Canadian Society of Nephrology; Heart and Stroke Foundation of Canada; Canadian Institutes of Health Research; Genome Canada; Sanofi; AstraZeneca","keywords":"Mendelian randomization; Biomarker; Genome-wide association study; Biology; Proteome; Renal function; Medicine; Genetics; Single-nucleotide polymorphism; Gene; Genotype; Endocrinology; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005518378,0.0002448146,0.000314099,0.0004263202,0.00008937949,0.00009211076,0.0001187529,0.0001171039,0.0001802381],"category_scores_gemma":[0.001114492,0.0002357257,0.00006969202,0.0005239906,0.00005594943,0.0003480587,0.00006595997,0.0001685731,0.00006232789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001670577,"about_ca_system_score_gemma":0.0003100165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000106437,"about_ca_topic_score_gemma":0.00001643389,"domain_scores_codex":[0.9981213,0.00008251773,0.0005625378,0.0005311283,0.0004108452,0.0002916952],"domain_scores_gemma":[0.9989889,0.00008872295,0.0001813373,0.0002491697,0.0001850212,0.0003068473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007596948,0.001102449,0.08727606,0.0002348452,0.0002128097,0.00004722487,0.0005068324,0.001821743,0.9052052,0.0000611115,0.002251328,0.0005206497],"study_design_scores_gemma":[0.03752043,0.0003196856,0.4210564,0.0008435152,0.0001783883,0.00001867796,0.0003546175,0.3992189,0.1382341,0.0003146693,0.001460165,0.0004804669],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862482,0.0001537931,0.005887147,0.003526965,0.000214212,0.003465471,0.0001744479,0.0002440528,0.00008570828],"genre_scores_gemma":[0.9925338,0.00005234644,0.003535394,0.0002259426,0.0001224871,0.0006048781,0.002079706,0.00004079692,0.0008046401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7669711,"threshold_uncertainty_score":0.9612614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03145710691514161,"score_gpt":0.300458571643587,"score_spread":0.2690014647284454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}