{"id":"W4387095938","doi":"10.7554/elife.90274","title":"Dual recognition of multiple signals in bacterial outer membrane proteins enhances assembly and maintains membrane integrity","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact","funders":"Japan Science and Technology Agency; Waksman Foundation of Japan; National Health and Medical Research Council; Japan Society for the Promotion of Science; Sumitomo Foundation; Tokyo Biochemical Research Foundation; Australian Research Council; Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care; Shinnihon Foundation of Advanced Medical Treatment Research; Uehara Memorial Foundation; Japan Agency for Medical Research and Development; Naito Foundation","keywords":"Cell biology; Bacterial outer membrane; Membrane; Membrane integrity; Membrane protein; Dual (grammatical number); Structural integrity; Translocase of the outer membrane; Chemistry; Biology; Biophysics; Biochemistry; Protein targeting; Gene; Escherichia coli; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001675409,0.0002799327,0.0002791069,0.0001021246,0.0001403402,0.000375107,0.0002514851,0.000345789,0.001514188],"category_scores_gemma":[0.0001665905,0.0001492755,0.0002095975,0.00009987239,0.0002837278,0.0002874029,0.0004597809,0.0008026383,0.0007000216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003130871,"about_ca_system_score_gemma":0.0002249077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001964308,"about_ca_topic_score_gemma":0.000337404,"domain_scores_codex":[0.9997976,0.00002111155,0.00001127227,0.00005283748,0.00005933487,0.00005774388],"domain_scores_gemma":[0.9998535,0.00001875106,0.00003495085,0.00001440362,0.00001916601,0.00005927596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007153652,0.00001364331,0.00006034519,0.00001575839,0.000001108962,0.00001786637,0.000004095505,0.00002302921,0.9990716,0.00009259271,0.00002297292,0.0006053618],"study_design_scores_gemma":[0.000008010499,0.00006660692,0.0005624305,0.000002170295,0.000002518751,0.0000707302,0.00001001838,0.0004732785,0.9978338,0.00003500271,0.0009329944,0.000002550109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990815,0.001036888,0.006147693,0.0002217463,0.00005910504,0.00001197838,0.00009940554,0.0001025056,0.001505783],"genre_scores_gemma":[0.9893273,0.0003412227,0.007017227,0.0001316712,0.00001325073,0.00001377997,0.0001510386,0.00003712072,0.002967473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001514188,"threshold_uncertainty_score":0.005065501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0211445192074315,"score_gpt":0.256677795670809,"score_spread":0.2355332764633775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}