{"id":"W4387100945","doi":"10.1183/16000617.0100-2023","title":"Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis","year":2023,"lang":"en","type":"review","venue":"European Respiratory Review","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute","keywords":"mTORC1; EIF4E; Eukaryotic translation; Eukaryotic initiation factor; Ribosome biogenesis; P70-S6 Kinase 1; Translation (biology); Mechanistic target of rapamycin; PI3K/AKT/mTOR pathway; Lymphangioleiomyomatosis; Ribosomal protein s6; Cancer research; Ribosomal s6 kinase; Medicine; Tuberous sclerosis; Cell biology; Protein biosynthesis; Ribosome; Biology; Messenger RNA; Genetics; Signal transduction; Gene; RNA; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002499469,0.0008434481,0.004327364,0.0008601999,0.0001034315,0.00006323085,0.000727995,0.0002136074,0.0005400205],"category_scores_gemma":[0.001001631,0.0006954553,0.001664566,0.002963391,0.0001132899,0.00008774253,0.0001740846,0.0006014184,0.006452444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004009927,"about_ca_system_score_gemma":0.0008991012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002575876,"about_ca_topic_score_gemma":0.000006560881,"domain_scores_codex":[0.992248,0.002652756,0.002340558,0.001182579,0.0006805934,0.0008955236],"domain_scores_gemma":[0.9966692,0.0007202717,0.0005332818,0.001425616,0.0002446906,0.0004069872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001448998,0.00008212483,0.00000565619,0.2887456,0.0001751603,0.0001861681,0.00001088358,9.561479e-8,0.000004189449,0.00002034178,0.02295635,0.6877989],"study_design_scores_gemma":[0.0007278216,0.0002351314,0.00004748322,0.2774513,0.0007978986,0.00004576074,0.000001138397,0.000002569431,4.359404e-7,0.000002568483,0.7202877,0.0004001862],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000001296783,0.9853472,0.00006052332,0.0001856144,0.0001636083,0.009363837,0.000199202,0.0003012629,0.004377496],"genre_scores_gemma":[1.838811e-7,0.9940543,0.0008663794,0.001628077,0.0006540366,0.000926558,0.000452827,0.0005798915,0.0008378088],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6973313,"threshold_uncertainty_score":0.9995497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3703190594430394,"score_gpt":0.4359822747222808,"score_spread":0.06566321527924146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}