{"id":"W4387100945","doi":"10.1183/16000617.0100-2023","title":"Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis","year":2023,"lang":"en","type":"review","venue":"European Respiratory Review","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute","keywords":"mTORC1; EIF4E; Eukaryotic translation; Eukaryotic initiation factor; Ribosome biogenesis; P70-S6 Kinase 1; Translation (biology); Mechanistic target of rapamycin; PI3K/AKT/mTOR pathway; Lymphangioleiomyomatosis; Ribosomal protein s6; Cancer research; Ribosomal s6 kinase; Medicine; Tuberous sclerosis; Cell biology; Protein biosynthesis; Ribosome; Biology; Messenger RNA; Genetics; Signal transduction; Gene; RNA; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004418569,0.0006006563,0.001215631,0.001378586,0.0002278759,0.001004875,0.0008051363,0.0009764591,0.003566828],"category_scores_gemma":[0.0005867232,0.0001856327,0.000464605,0.001222236,0.0003088612,0.001158197,0.0005675482,0.001742093,0.00208504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005032372,"about_ca_system_score_gemma":0.001045908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000594116,"about_ca_topic_score_gemma":0.001501661,"domain_scores_codex":[0.9998232,0.00003231421,0.00003419596,0.00002823602,0.00006055009,0.00002154305],"domain_scores_gemma":[0.9998119,0.00008106673,0.00003107492,0.000004964041,0.00005110036,0.0000197769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001297691,0.00004698249,0.00008352139,0.02971512,0.0001509551,0.0002377112,0.000055452,0.0001621217,0.001907189,0.00246041,0.04791912,0.9171318],"study_design_scores_gemma":[0.00003385642,0.0001214592,0.0005651169,0.005582424,0.0002250184,0.001516795,0.00005107683,0.00006132505,0.0004397955,0.001315403,0.990072,0.00001562183],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006468176,0.9990633,0.00003787314,0.0002062615,0.0002483884,0.00000208252,0.00001045465,0.000005104581,0.0003618808],"genre_scores_gemma":[0.0005370764,0.9982979,0.00009761547,0.0004228978,0.0001857511,0.000004879856,0.00003315547,0.000001714954,0.0004190713],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003566828,"threshold_uncertainty_score":0.01193225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3703190594430394,"score_gpt":0.4359822747222808,"score_spread":0.06566321527924146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}