{"id":"W4387103580","doi":"10.1101/2023.09.20.558508","title":"An RNA foundation model enables discovery of disease mechanisms and candidate therapeutics","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Genomics","funders":"","keywords":"RNA; RNA splicing; Computational biology; Biology; Polyadenylation; Intron; Exon; Gene; Genetics; Non-coding RNA; Alternative splicing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001107196,0.0005966003,0.0006958015,0.000576495,0.0003545349,0.0008371645,0.0008451351,0.001253158,0.002999631],"category_scores_gemma":[0.002802774,0.0003722588,0.001142341,0.0002765824,0.0006707819,0.0007595436,0.0006596051,0.001165909,0.0004890143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008422706,"about_ca_system_score_gemma":0.001536485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004166675,"about_ca_topic_score_gemma":0.004198554,"domain_scores_codex":[0.9997392,0.00009854859,0.000009379322,0.00006939699,0.00004580326,0.00003767268],"domain_scores_gemma":[0.9989125,0.0007314275,0.00009727862,0.0000766027,0.0001010421,0.00008113512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001333218,0.00003817418,0.002012158,0.0000448462,0.00005933365,0.0001659841,0.00001838948,0.9541178,0.001876724,0.0269411,0.002401846,0.01219042],"study_design_scores_gemma":[0.0000114971,0.00001322183,0.00006539402,0.000003129727,0.000006107399,0.00001387132,0.000001627285,0.9917229,0.0002058683,0.007446498,0.0005069273,0.000002996463],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1611721,0.0006391567,0.8171554,0.002932414,0.0002267441,0.0001176332,0.00216801,0.002302616,0.01328596],"genre_scores_gemma":[0.8826033,0.0003607469,0.1066409,0.0005105133,0.000112928,0.0003130535,0.001477204,0.0002274687,0.007753942],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.004166675,"threshold_uncertainty_score":0.0100348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02049002437704721,"score_gpt":0.2615424899564699,"score_spread":0.2410524655794227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}