{"id":"W4387105833","doi":"10.3390/curroncol30100635","title":"The Combined Therapy of Cabozantinib, Crizotinib, and Osimertinib in a Lung Cancer Patient with Acquired MET Amplification and Resistance Mutations","year":2023,"lang":"en","type":"article","venue":"Current Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Crizotinib; Osimertinib; Cabozantinib; Medicine; Lung cancer; Acquired resistance; Adenocarcinoma; Oncology; Targeted therapy; Cancer research; Point mutation; Tyrosine-kinase inhibitor; Erlotinib; Internal medicine; Cancer; Mutation; Epidermal growth factor receptor; ROS1; Genetics; Biology; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001296421,0.0005533706,0.0005815928,0.0006403502,0.0007612242,0.0004986478,0.0003649119,0.001679618,0.001152145],"category_scores_gemma":[0.0004349018,0.0002971355,0.0006159337,0.0003813775,0.0004529609,0.0005574522,0.0003868065,0.001531248,0.0004131703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008413547,"about_ca_system_score_gemma":0.0005857685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002001831,"about_ca_topic_score_gemma":0.005993309,"domain_scores_codex":[0.9998426,0.00001842445,0.00001744005,0.00004362122,0.00002864588,0.00004926081],"domain_scores_gemma":[0.9998044,0.00003681429,0.00002886945,0.000009336489,0.00001345305,0.0001071396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0003250446,0.0001220165,0.02403338,0.00004923508,0.00002918423,0.9540932,0.0001987462,0.0002409576,0.009920989,0.0002125965,0.0008334093,0.00994119],"study_design_scores_gemma":[0.00003013299,0.000488994,0.01589722,0.00001449311,0.00005824571,0.975397,0.0001267159,0.001094779,0.004715649,0.0001627182,0.001996741,0.00001733471],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778491,0.00381338,0.002324188,0.005052313,0.0001719065,0.0001053064,0.0002098187,0.0001395717,0.01033435],"genre_scores_gemma":[0.9959612,0.0008366734,0.0008154377,0.0006867856,0.0001543939,0.000007360566,0.00007856648,0.00001014996,0.001449473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002001831,"threshold_uncertainty_score":0.006104469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05721777822825429,"score_gpt":0.4320573635367528,"score_spread":0.3748395853084985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}