{"id":"W4387107787","doi":"10.1016/j.gtc.2023.08.005","title":"Management of Monogenic and Syndromic Obesity","year":2023,"lang":"en","type":"review","venue":"Gastroenterology Clinics of North America","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Ciliopathies; Leptin receptor; Bardet–Biedl syndrome; Leptin; Proopiomelanocortin; Obesity; Proprotein convertase; Population; Genetics; Internal medicine; Bioinformatics; Endocrinology; Gene; Receptor; Biology; LDL receptor; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004733399,0.0009811129,0.001353663,0.001889172,0.000201223,0.0008239571,0.0009655134,0.001072398,0.001449383],"category_scores_gemma":[0.0008092715,0.0001828174,0.0005238533,0.0008850056,0.0003381061,0.0006746115,0.0006748128,0.001940326,0.000760301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003753813,"about_ca_system_score_gemma":0.0005285378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006515684,"about_ca_topic_score_gemma":0.001284102,"domain_scores_codex":[0.9998415,0.0000358164,0.0000227445,0.00002482356,0.00005595918,0.00001926654],"domain_scores_gemma":[0.999797,0.00009927754,0.00003487709,0.000005319245,0.00003072092,0.00003274778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001012877,0.00006666772,0.0004896389,0.005027164,0.0001076644,0.001913227,0.0000247299,0.0004476963,0.0006475782,0.001344712,0.02462647,0.9652032],"study_design_scores_gemma":[0.0002001377,0.0002764386,0.005842855,0.01254552,0.0006357505,0.03644873,0.0002120945,0.0008137598,0.0009351202,0.005774346,0.936243,0.00007225181],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001659152,0.9983585,0.0002864785,0.0003419573,0.000226326,0.000002924975,0.00000976627,0.000008764317,0.0005992716],"genre_scores_gemma":[0.001804012,0.9959546,0.0005689028,0.0004146384,0.000744791,0.000007200496,0.00004679881,0.000002399278,0.0004565135],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001889172,"threshold_uncertainty_score":0.004848659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02548695728347827,"score_gpt":0.3056754722720263,"score_spread":0.280188514988548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}