{"id":"W4387114306","doi":"10.1128/msphere.00162-23","title":"Vaborbactam increases meropenem susceptibility in <i>Pseudomonas aeruginosa</i> clinical isolates displaying MexXY and AmpC upregulation","year":2023,"lang":"en","type":"article","venue":"mSphere","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Center, University of Rochester; National Institutes of Health; Idorsia Pharmaceuticals; Wockhardt; TenNor Therapeutics; Astellas Foundation for Research on Metabolic Disorders; Basilea Pharmaceutica; Astellas Pharma; North Bristol NHS Trust; Shionogi; Meiji Seika Pharma; University of Queensland; Pfizer; Melinta Therapeutics; Entasis Therapeutics; Albany College of Pharmacy and Health Sciences; Achaogen; Amplyx; Roivant Sciences; National University of Singapore; Nabriva Therapeutics; GenePOC; University of Texas Southwestern Medical Center; Medicines Company; University of North Texas; Novartis; Harvard University; F. Hoffmann-La Roche; Wayne State University; Medpace; GlaxoSmithKline; Allergan; Cidara Therapeutics; University of Southern California; Tufts Medical Center; Bayer; Beth Israel Deaconess Medical Center","keywords":"Pseudomonas aeruginosa; Meropenem; Microbiology; Biology; Pseudomonadaceae; Gene; Antibiotics; Bacteria; Antibiotic resistance; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005067343,0.000176733,0.0002402639,0.0000221797,0.00007759294,0.0000492628,0.0001593079,0.000215,0.00005320403],"category_scores_gemma":[0.0002787287,0.0001663505,0.0000724837,0.0001868726,0.0001708203,0.00001383283,0.0001968592,0.0001155234,0.00002886638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001538569,"about_ca_system_score_gemma":0.00005108945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001699617,"about_ca_topic_score_gemma":0.001205831,"domain_scores_codex":[0.9984875,0.0001803802,0.0004118412,0.0005343931,0.0000987113,0.0002871146],"domain_scores_gemma":[0.9992694,0.00008800381,0.0001025892,0.0004035834,0.00004571492,0.00009065684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001430077,0.000059483,0.8523669,0.00003481711,0.00002156164,0.00000651615,0.00002171532,0.00002509417,0.1430642,0.00003740206,0.00141397,0.00280537],"study_design_scores_gemma":[0.0006316457,0.0001110803,0.9868621,0.00005566592,0.00001474138,0.00000510573,0.0001997575,0.0002678197,0.008367036,0.0001457685,0.003109348,0.0002299278],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984448,0.0004005243,0.00007861054,0.0001048271,0.000135384,0.000216404,0.00001978133,0.00003835966,0.0005613377],"genre_scores_gemma":[0.9979403,0.0006271121,0.0005739048,0.00008999648,0.0001569821,0.000006777912,0.0001644977,0.00002639229,0.000414049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1346971,"threshold_uncertainty_score":0.6783575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171291879111278,"score_gpt":0.2985685197722674,"score_spread":0.2814393318611397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}