{"id":"W4387114306","doi":"10.1128/msphere.00162-23","title":"Vaborbactam increases meropenem susceptibility in <i>Pseudomonas aeruginosa</i> clinical isolates displaying MexXY and AmpC upregulation","year":2023,"lang":"en","type":"article","venue":"mSphere","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Center, University of Rochester; National Institutes of Health; Idorsia Pharmaceuticals; Wockhardt; TenNor Therapeutics; Astellas Foundation for Research on Metabolic Disorders; Basilea Pharmaceutica; Astellas Pharma; North Bristol NHS Trust; Shionogi; Meiji Seika Pharma; University of Queensland; Pfizer; Melinta Therapeutics; Entasis Therapeutics; Albany College of Pharmacy and Health Sciences; Achaogen; Amplyx; Roivant Sciences; National University of Singapore; Nabriva Therapeutics; GenePOC; University of Texas Southwestern Medical Center; Medicines Company; University of North Texas; Novartis; Harvard University; F. Hoffmann-La Roche; Wayne State University; Medpace; GlaxoSmithKline; Allergan; Cidara Therapeutics; University of Southern California; Tufts Medical Center; Bayer; Beth Israel Deaconess Medical Center","keywords":"Pseudomonas aeruginosa; Meropenem; Microbiology; Biology; Pseudomonadaceae; Gene; Antibiotics; Bacteria; Antibiotic resistance; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008942383,0.0002255621,0.0003276277,0.0002207741,0.0001342673,0.0005255826,0.0001117655,0.0002777461,0.00161313],"category_scores_gemma":[0.0003346108,0.0001352585,0.0002479101,0.0002331508,0.0001436361,0.0001800512,0.0002231973,0.0003417176,0.000346268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001631716,"about_ca_system_score_gemma":0.0001323349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007281583,"about_ca_topic_score_gemma":0.0008849254,"domain_scores_codex":[0.9998069,0.00002733531,0.00001889891,0.00004574185,0.0000544935,0.00004664166],"domain_scores_gemma":[0.9998025,0.00002773649,0.00008040367,0.00001363553,0.00004075771,0.0000349605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002330624,0.00003019702,0.008494313,0.00007836478,0.00001248806,0.0001034192,0.00003415172,0.00002915179,0.9884052,0.00001041459,0.0001219041,0.002447229],"study_design_scores_gemma":[0.00003961911,0.001858476,0.5138524,0.00006609116,0.0001119107,0.002515072,0.0008081477,0.001083375,0.4743454,0.00009105327,0.005201666,0.00002673346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981045,0.0006960914,0.0001577437,0.00009176116,0.000009618591,0.00001144562,0.0004640575,0.00004074709,0.000424061],"genre_scores_gemma":[0.998283,0.0002654525,0.0003627916,0.00008626492,0.000009032501,0.00001199371,0.0006066877,0.00001188393,0.0003627991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00161313,"threshold_uncertainty_score":0.005396485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171291879111278,"score_gpt":0.2985685197722674,"score_spread":0.2814393318611397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}