{"id":"W4387114395","doi":"10.1007/s00395-023-01007-z","title":"The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury","year":2023,"lang":"en","type":"review","venue":"Basic Research in Cardiology","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Proteases; Calpain; Ischemia; Proteolysis; Reperfusion injury; Intracellular; Matrix metalloproteinase; Cathepsin; Medicine; Caspase; Protease; Cardiology; Pharmacology; Cell biology; Apoptosis; Internal medicine; Biology; Programmed cell death; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006792807,0.0002534284,0.0011445,0.0004941412,0.0001083127,0.00001941209,0.0004518999,0.0008784586,0.000004840416],"category_scores_gemma":[0.0009433539,0.0001746698,0.0005700175,0.0009774786,0.0004463591,0.000002966353,0.0005335361,0.0008498022,0.00002979857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001201173,"about_ca_system_score_gemma":0.0006057324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004871441,"about_ca_topic_score_gemma":0.00007065877,"domain_scores_codex":[0.9944816,0.003154767,0.0007691301,0.0006521507,0.000391186,0.0005511475],"domain_scores_gemma":[0.998322,0.0003798016,0.0001749509,0.0008781332,0.0001751927,0.00006988321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001375131,0.0000285548,0.0002008865,0.002955441,0.0002431739,0.00002750444,0.00002127097,0.00003892877,0.01097491,0.0001256838,0.004065292,0.9811808],"study_design_scores_gemma":[0.0001558958,0.0001395172,0.00002051219,0.001280322,0.00003760966,0.000009647461,0.00008738075,0.00001255683,0.003503372,0.0001304817,0.9944463,0.0001764443],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005348211,0.9919031,0.00002616616,0.00009653379,0.0002705817,0.001926587,0.00004479026,0.000009953867,0.0003740752],"genre_scores_gemma":[0.001534559,0.9953979,0.00001452466,0.000003339487,0.0005338468,0.001209362,0.0003263386,0.00005016553,0.0009299614],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9903809,"threshold_uncertainty_score":0.7122827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07745220210131844,"score_gpt":0.4013481340118926,"score_spread":0.3238959319105742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}