{"id":"W4387116257","doi":"10.1002/biot.202300244","title":"Development, optimization, and scale‐up of suspension Vero cell culture process for high titer production of oncolytic herpes simplex virus‐1","year":2023,"lang":"en","type":"article","venue":"Biotechnology Journal","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Vero cell; Titer; Multiplicity of infection; Bioreactor; Herpes simplex virus; Cell culture; Oncolytic virus; Biology; Virology; Virus; Microcarrier; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007283447,0.0006609084,0.0006853006,0.0003474718,0.0003403275,0.001062081,0.0005215985,0.0004972405,0.0005249072],"category_scores_gemma":[0.000533342,0.0002597054,0.0005959166,0.0003830069,0.000227806,0.0004897882,0.0004136744,0.001090113,0.0006181858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003563005,"about_ca_system_score_gemma":0.0004171448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001217494,"about_ca_topic_score_gemma":0.001191951,"domain_scores_codex":[0.9995155,0.000071031,0.00006588763,0.000115861,0.0001822555,0.00004939219],"domain_scores_gemma":[0.9997961,0.00005048901,0.00003854009,0.00003309054,0.00005887977,0.00002295807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002308455,0.00005304151,0.0001755721,0.00006292448,0.000005966038,0.00006342072,0.00003141808,0.0003893333,0.9966307,0.00005468662,0.00007322668,0.002436569],"study_design_scores_gemma":[0.000008147254,0.0002282405,0.0008560451,0.00001249396,0.0000269017,0.00008029902,0.00002586265,0.003041701,0.9931127,0.00004249226,0.002550444,0.00001469495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8366314,0.003932281,0.1515745,0.0002766073,0.0002814294,0.001008809,0.001862901,0.0008228663,0.003609221],"genre_scores_gemma":[0.8209782,0.004420656,0.1649968,0.0001027244,0.00005963778,0.0009031659,0.004271255,0.0001922139,0.004075314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001217494,"threshold_uncertainty_score":0.003851891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01892199507557242,"score_gpt":0.3023097652011554,"score_spread":0.283387770125583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}