{"id":"W4387116257","doi":"10.1002/biot.202300244","title":"Development, optimization, and scale‐up of suspension Vero cell culture process for high titer production of oncolytic herpes simplex virus‐1","year":2023,"lang":"en","type":"article","venue":"Biotechnology Journal","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Vero cell; Titer; Multiplicity of infection; Bioreactor; Herpes simplex virus; Cell culture; Oncolytic virus; Biology; Virology; Virus; Microcarrier; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003145264,0.0001058713,0.0001556612,0.0001760224,0.0001152507,0.000008204667,0.0001636201,0.0003262493,0.00001105282],"category_scores_gemma":[0.00007968712,0.00009083197,0.00003412255,0.0002556561,0.000162658,0.000007029797,0.00006871419,0.0001155051,0.000001445988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001634798,"about_ca_system_score_gemma":0.0001605016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001198427,"about_ca_topic_score_gemma":0.0000267681,"domain_scores_codex":[0.9991621,0.00002876094,0.00026539,0.0002214429,0.0001264261,0.0001958576],"domain_scores_gemma":[0.9993233,0.000005936858,0.0001821164,0.000160937,0.0002892542,0.00003844342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006705438,0.00005636871,0.0001093838,0.00007886775,0.00004435397,8.239392e-7,0.0001334018,0.0008370951,0.9874512,0.000004439855,0.001305707,0.009307818],"study_design_scores_gemma":[0.0007771703,0.0009045764,0.0001074013,0.0000260572,0.00001247497,0.00002764029,0.0001935814,0.0001375826,0.9919692,0.0001048657,0.005645155,0.00009427176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971743,0.0003303425,0.001610285,0.0004734027,0.0001227517,0.0002555958,0.000008636621,0.0000176095,0.000007041403],"genre_scores_gemma":[0.9937136,0.001317662,0.004242382,0.0000250723,0.00009098405,0.00001554894,0.00005776392,0.00002184157,0.0005151387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009213545,"threshold_uncertainty_score":0.370402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01892199507557242,"score_gpt":0.3023097652011554,"score_spread":0.283387770125583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}