{"id":"W4387118370","doi":"10.1101/2023.09.27.559313","title":"Systematic perturbations of SETD2, NSD1, NSD2, NSD3 and ASH1L reveals their distinct contributions to H3K36 methylation","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre","funders":"National Institutes of Health; Faculty of Medicine and Health, University of Sydney; McGill University","keywords":"Methylation; Methyltransferase; Chemistry; Environmental chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233552,0.0002918775,0.0001588434,0.0002314612,0.0001733637,0.0002643858,0.000296731,0.0002370939,0.001525627],"category_scores_gemma":[0.0001292965,0.0001440237,0.0002563562,0.0002098399,0.0003314344,0.0001490507,0.0003129289,0.0005205949,0.0003020663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004342023,"about_ca_system_score_gemma":0.0002219315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009398776,"about_ca_topic_score_gemma":0.001658249,"domain_scores_codex":[0.9998626,0.00001126099,0.00001420337,0.00003903668,0.00004442464,0.00002850972],"domain_scores_gemma":[0.99986,0.00002761764,0.00004075461,0.00002017865,0.00001497604,0.00003635928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001140416,0.00001513576,0.0004224378,0.00001806895,0.000005504743,0.00001442989,0.000006886824,0.0001151408,0.9986001,0.00005785226,0.00002257265,0.0006079074],"study_design_scores_gemma":[0.000007166914,0.00008491985,0.00285123,0.000001722213,0.00001316233,0.00004556461,0.00001772682,0.001217217,0.9947664,0.00003169077,0.0009602646,0.00000297936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937546,0.0007110687,0.00294196,0.00006445291,0.00002238088,0.00002464836,0.001175795,0.00007838471,0.001226651],"genre_scores_gemma":[0.9945524,0.0003733679,0.001874187,0.00004869485,0.000002809851,0.00003835138,0.001000987,0.00003389937,0.002075325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001525627,"threshold_uncertainty_score":0.005103767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01568852061245574,"score_gpt":0.2571926881381403,"score_spread":0.2415041675256846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}