{"id":"W4387121752","doi":"10.1016/j.crbiot.2023.100147","title":"Strong expression of Cas9 under a new 3′-truncated TEF1α promoter enhances genome editing in Yarrowia lipolytica","year":2023,"lang":"en","type":"article","venue":"Current Research in Biotechnology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Genome editing; Cas9; Genome; Yarrowia; Genetics; Gene; CRISPR; Promoter; Computational biology; Biology; Chemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005930956,0.0001391228,0.0001912828,0.0007226287,0.00003565544,0.00001155494,0.0003754551,0.0003532969,0.00002313394],"category_scores_gemma":[0.0002017185,0.0001342669,0.00004064821,0.0009988693,0.0001900595,0.000004855631,0.0004656356,0.0005582852,0.00002078568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003894288,"about_ca_system_score_gemma":0.00013227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006138667,"about_ca_topic_score_gemma":0.0001378226,"domain_scores_codex":[0.9982828,0.00007736048,0.0003157192,0.0004466988,0.0002250804,0.0006523148],"domain_scores_gemma":[0.9994131,0.00003156615,0.00004288105,0.0003867507,0.00005159407,0.00007415446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002342175,0.00005205238,0.001036416,0.00007264681,0.000005614176,0.000006942278,0.00006260365,0.0003187789,0.9882236,0.0001324756,0.0003282155,0.009737223],"study_design_scores_gemma":[0.0004540657,0.000190246,0.004276508,0.0001647014,0.000001588022,0.000004255324,0.0002611706,0.000506659,0.9875816,0.0004191627,0.006004775,0.0001352894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994287,0.002684846,0.001538594,0.0008323386,0.0001970785,0.0003271331,0.000008278061,0.0000408699,0.00008383293],"genre_scores_gemma":[0.9982824,0.001086033,0.0002389732,0.000002544135,0.0001570783,0.000041354,0.00006287946,0.00002004506,0.0001086524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009601934,"threshold_uncertainty_score":0.5475246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06456743369161637,"score_gpt":0.4249950085222469,"score_spread":0.3604275748306305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}