{"id":"W4387125398","doi":"10.2337/dc23-0748","title":"DNA Methylation at <i>ABCG1</i> and Long-term Changes in Adiposity and Fat Distribution in Response to Dietary Interventions: The POUNDS Lost Trial","year":2023,"lang":"en","type":"article","venue":"Diabetes Care","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Fogarty International Center; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; American Heart Association","keywords":"Adipose tissue; Medicine; Waist; Overweight; Internal medicine; DNA methylation; Endocrinology; Obesity; Methylation; Weight loss; Physiology; Biology; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00144726,0.0005428914,0.001310716,0.0001763882,0.0002626865,0.0007666335,0.0003763753,0.0008605447,0.00221392],"category_scores_gemma":[0.001654354,0.0002471023,0.001203832,0.0002661445,0.0005906856,0.0004802888,0.0003955595,0.001179508,0.000221639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003189754,"about_ca_system_score_gemma":0.0003385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001204629,"about_ca_topic_score_gemma":0.00111205,"domain_scores_codex":[0.9995744,0.0002229714,0.0000282238,0.00007545858,0.0000504347,0.00004859907],"domain_scores_gemma":[0.999455,0.0001116011,0.0002221235,0.00006391089,0.00004088086,0.00010645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8698297,0.004647296,0.0561506,0.001375599,0.007078054,0.0001007589,0.0001409263,0.000648658,0.006319629,0.0001644785,0.001305731,0.05223854],"study_design_scores_gemma":[0.4821633,0.2130808,0.2769067,0.0005785544,0.01433667,0.0003144698,0.0002990365,0.001980902,0.00387266,0.00095083,0.005443559,0.00007264889],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957342,0.002672919,0.0002282505,0.0003522307,0.00007342942,0.0001407828,0.000258224,0.00001736911,0.0005226768],"genre_scores_gemma":[0.9967129,0.0007174498,0.0002754044,0.0004632001,0.00008883497,0.0003222403,0.0003853994,0.00000722772,0.001027141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00221392,"threshold_uncertainty_score":0.007653952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02251884413525866,"score_gpt":0.293249106261454,"score_spread":0.2707302621261953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}