{"id":"W4387128991","doi":"10.1007/s12325-023-02666-z","title":"Efficacy and Safety of Single-Pill Combination of Rosuvastatin and Ezetimibe in Chinese Patients with Primary Hypercholesterolemia Inadequately Controlled by Statin Treatment (ROZEL): A Randomized, Double-Blind, Double Dummy, Active-Controlled Phase 3 Clinical Trial","year":2023,"lang":"en","type":"article","venue":"Advances in Therapy","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"","keywords":"Medicine; Rosuvastatin; Statin; Double blind; Ezetimibe; Randomized controlled trial; Internal medicine; Pill; Simvastatin; Single blind; Atorvastatin; Rheumatology; Pharmacology; Alternative medicine; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002261549,0.0003063756,0.002923928,0.000263103,0.00004132459,0.00001330767,0.00006720032,0.0001220277,0.000006166714],"category_scores_gemma":[0.0001816598,0.0001855062,0.0002344557,0.0004034761,0.0002807874,0.0002298053,0.00002124122,0.0001977851,3.253733e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001157116,"about_ca_system_score_gemma":0.0001399291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001899544,"about_ca_topic_score_gemma":0.00008081223,"domain_scores_codex":[0.9966347,0.0007173661,0.001461916,0.0004297351,0.0004807404,0.0002755428],"domain_scores_gemma":[0.9973912,0.001426683,0.0006293622,0.0002917778,0.0001455361,0.0001154656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7995198,0.004766239,0.005030103,0.00007772977,0.0004291825,0.000006919917,0.0007767751,0.00004617285,0.0002386314,0.0000169783,9.577436e-7,0.1890905],"study_design_scores_gemma":[0.9774889,0.01144543,0.009791143,0.0001829032,0.0001459255,0.000001844632,0.00009354905,0.0001819028,0.0003267433,0.0000922983,0.00009681525,0.0001525735],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821041,0.003894188,0.0001022001,0.0001789441,0.0000966147,0.01346068,0.00004005514,0.00002212306,0.000101086],"genre_scores_gemma":[0.9840353,0.01438836,0.0003117971,0.00006510843,0.00003903323,0.0008785813,0.0002221542,0.00003251305,0.0000272091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1889379,"threshold_uncertainty_score":0.7564722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0329011302102163,"score_gpt":0.3614932351858793,"score_spread":0.328592104975663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}