{"id":"W4387130648","doi":"10.1038/s41594-023-01095-4","title":"Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD","year":2023,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Medical Research Council; Wellcome Trust","keywords":"Enhancer; Chromatin; Nucleosome; Cell biology; Biology; Chromatin remodeling; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001426486,0.0003210778,0.0003251602,0.00009853055,0.00009369827,0.00001909836,0.0003538564,0.0008854538,0.000024448],"category_scores_gemma":[0.00008809171,0.0003051806,0.0002040394,0.0002509568,0.0001504161,0.000005834569,0.0002089893,0.0003489457,0.000008625561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005118232,"about_ca_system_score_gemma":0.00005334331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002388378,"about_ca_topic_score_gemma":0.0000529934,"domain_scores_codex":[0.9982451,0.00009655263,0.0004162664,0.0006208205,0.00017896,0.0004422963],"domain_scores_gemma":[0.9989516,0.00001990351,0.0002819661,0.0004478148,0.0002182394,0.00008044233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000491402,0.00002008037,0.001158776,0.00003175575,0.00006766433,0.00000553303,0.00001509262,0.0009580711,0.9945087,0.0006406953,0.0005090933,0.002035373],"study_design_scores_gemma":[0.0009016471,0.0005678662,0.005660564,0.00002765903,0.00005077891,0.0000368526,0.00003302692,0.03814822,0.9474094,0.006284836,0.0002660976,0.0006130626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933186,0.001441578,0.003822907,0.0002105348,0.0004100998,0.0002675449,0.0002924248,0.00003584202,0.0002005379],"genre_scores_gemma":[0.9933725,0.0000292869,0.001915139,0.0002597913,0.00009965654,0.00001087019,0.004097432,0.00005499699,0.0001603124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04709934,"threshold_uncertainty_score":0.99994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004220284931335071,"score_gpt":0.2548443401999009,"score_spread":0.2506240552685658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}