{"id":"W4387130674","doi":"10.1007/s00277-023-05462-5","title":"TP53-mutated acute myeloid leukemia and myelodysplastic syndrome: biology, treatment challenges, and upcoming approaches","year":2023,"lang":"en","type":"review","venue":"Annals of Hematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Clinical trial; Venetoclax; Azacitidine; Myeloid leukemia; Myelodysplastic syndromes; Medicine; Myeloid; Oncology; Hematology; Immunotherapy; Internal medicine; Immunology; Immune system; Leukemia; Biology; Chronic lymphocytic leukemia; Bone marrow; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001166972,0.0007296205,0.00222778,0.001556498,0.0002685509,0.001430741,0.001198947,0.001368781,0.00440417],"category_scores_gemma":[0.001772732,0.0002609004,0.000732077,0.001573828,0.0005303849,0.00200847,0.0008993033,0.002952689,0.00194126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000656774,"about_ca_system_score_gemma":0.001688365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009594401,"about_ca_topic_score_gemma":0.002679677,"domain_scores_codex":[0.9997184,0.00005965151,0.00004116395,0.00004345948,0.0001051304,0.00003223228],"domain_scores_gemma":[0.9991747,0.0004394779,0.00009862368,0.00001714283,0.0001969989,0.00007307761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000145295,0.00005881978,0.0002247056,0.0146385,0.0001309467,0.000192018,0.00003273598,0.0002869614,0.0006516798,0.003799248,0.05657536,0.9232637],"study_design_scores_gemma":[0.00006827374,0.0001299017,0.0007784839,0.008224859,0.0003037829,0.001207007,0.00007987072,0.0001398984,0.0001702687,0.002889069,0.9859823,0.00002633244],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003499577,0.9990118,0.00004304233,0.0004053576,0.0002342812,0.000001632985,0.00001071437,0.000003664545,0.000254499],"genre_scores_gemma":[0.0002889333,0.9986801,0.00009275683,0.0004099555,0.0003059141,0.000002772783,0.00002457455,9.047074e-7,0.0001941342],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00440417,"threshold_uncertainty_score":0.01473337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2947779957622806,"score_gpt":0.4145194577664131,"score_spread":0.1197414620041324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}