{"id":"W4387131136","doi":"10.21203/rs.3.rs-3392867/v1","title":"Uncovering the Neuroanatomical Signature of the Transition from Normal Cognition to Mild Cognitive Impairment in Parkinson's Disease: A VBM and Brain Age Estimation Study","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Engineering and Physical Sciences Research Council; Avid Radiopharmaceuticals; Parkinson Canada; Biogen; Bristol-Myers Squibb","keywords":"Cognition; Cognitive decline; Voxel-based morphometry; Neuroimaging; White matter; Grey matter; Parkinson's disease; Cerebellum; Voxel; Medicine; Neuroscience; Psychology; Cognitive impairment; Audiology; Internal medicine; Cardiology; Magnetic resonance imaging; Disease; Dementia; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008836383,0.000171487,0.000180192,0.001357801,0.0001920752,0.0004632761,0.0001951526,0.0002294249,0.0006043692],"category_scores_gemma":[0.001424421,0.0001168735,0.0002319145,0.0004402819,0.0002402461,0.000288111,0.0003149378,0.0001564939,0.00008632702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002002018,"about_ca_system_score_gemma":0.0001556656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003813657,"about_ca_topic_score_gemma":0.005001307,"domain_scores_codex":[0.9998772,0.00003955539,0.00001221048,0.00003432826,0.00002066039,0.00001612515],"domain_scores_gemma":[0.9995168,0.0001580878,0.0001513569,0.00007883321,0.00005692402,0.00003799248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001043456,0.0000799363,0.9409211,0.00005645501,0.0002315762,0.0004361898,0.0006674977,0.001408075,0.02741182,0.0002543252,0.0001677718,0.02732179],"study_design_scores_gemma":[0.000007673533,0.0001273161,0.9938766,0.000008041011,0.0000392876,0.0004583798,0.0002056965,0.00366779,0.001301417,0.0001407856,0.0001617713,0.000005270498],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987918,0.0001218267,0.0008704759,0.000009665044,0.000001612897,0.000004859583,0.00008183189,0.000006533898,0.0001114711],"genre_scores_gemma":[0.9990202,0.00003004893,0.0007781173,0.00000333786,0.000002085734,0.000002780513,0.0001190019,0.000001763196,0.0000426092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003813657,"threshold_uncertainty_score":0.007582903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04318831838115832,"score_gpt":0.3621781409187528,"score_spread":0.3189898225375944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}