{"id":"W4387132514","doi":"10.3390/curroncol30100640","title":"Fluctuation of Acquired Resistance Mutations and Re-Challenge with EGFR TKI in Metastatic NSCLC: A Case Report","year":2023,"lang":"en","type":"article","venue":"Current Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Osimertinib; T790M; Medicine; Epidermal growth factor receptor; Oncology; Liquid biopsy; Lung cancer; Internal medicine; Circulating tumor DNA; Cancer research; EGFR inhibitors; Cancer; Gefitinib; Erlotinib","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003021864,0.00198546,0.00149395,0.002243777,0.002606393,0.001870362,0.001328893,0.005980401,0.002251044],"category_scores_gemma":[0.002246465,0.0011779,0.00161858,0.001453203,0.001561493,0.002383652,0.001648793,0.004125292,0.001133314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001532971,"about_ca_system_score_gemma":0.000800497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003076678,"about_ca_topic_score_gemma":0.003471022,"domain_scores_codex":[0.9993432,0.00006103714,0.00006349643,0.0002156017,0.0001112523,0.0002053298],"domain_scores_gemma":[0.9987831,0.0002545505,0.0002502845,0.000110192,0.00009743462,0.0005045496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00001532709,0.00002175116,0.002631965,0.00001510163,0.000005172466,0.99602,0.0001047487,0.00003126241,0.0003169879,0.00007147769,0.0001552137,0.000610907],"study_design_scores_gemma":[0.000003216301,0.00002961966,0.001403281,0.000006417158,0.000007442699,0.9978549,0.00006045032,0.0001303046,0.0001732079,0.00005350568,0.000271146,0.000006517151],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706287,0.007623609,0.005100556,0.004224346,0.0004794155,0.0002372749,0.0003742697,0.0002316364,0.01110026],"genre_scores_gemma":[0.991842,0.002370805,0.001555084,0.001141605,0.0009290221,0.00003291801,0.0001374926,0.00004367865,0.001947495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005980401,"threshold_uncertainty_score":0.01112252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1040228860763081,"score_gpt":0.4526503482249069,"score_spread":0.3486274621485987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}