{"id":"W4387134972","doi":"10.1038/s41467-023-41793-7","title":"Acetylation reprograms MITF target selectivity and residence time","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"RIKEN; Cancer Research Society; Medical Research Council; Háskóli Íslands; Associazione Italiana per la Ricerca sul Cancro; National Institutes of Health; Cancer Research UK; Wellcome Trust; National Cancer Institute; Melanoma Research Alliance; Fondazione Italiana per la Ricerca sul Cancro; Rosetrees Trust; Ludwig Institute for Cancer Research","keywords":"Microphthalmia-associated transcription factor; Transcription factor; Acetylation; Biology; Cell biology; IRF4; SOX10; Cellular differentiation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008453708,0.0001508678,0.0001840771,0.0001947392,0.0001346946,0.0002648386,0.0001669556,0.0002040447,0.002246809],"category_scores_gemma":[0.0001905626,0.0001279307,0.0001473386,0.0001085521,0.0001697026,0.0001242608,0.0001488173,0.0002592531,0.0006574888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002493961,"about_ca_system_score_gemma":0.0001262419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000905913,"about_ca_topic_score_gemma":0.001395764,"domain_scores_codex":[0.999896,0.00001099017,0.000005916934,0.00003645016,0.00002465116,0.00002584349],"domain_scores_gemma":[0.9998616,0.00002949649,0.00003935306,0.0000195717,0.00001354632,0.00003643376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006208671,0.000004155748,0.0004346545,0.000005401838,0.000002135881,0.00002613602,0.000005139877,0.00002841417,0.9987873,0.00003516601,0.00001552646,0.0005939559],"study_design_scores_gemma":[0.000007370502,0.0000856082,0.02479703,0.000002521755,0.000007483001,0.0004440012,0.00002444718,0.0008875575,0.9723746,0.00007716854,0.001285131,0.000007072909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970974,0.0004626243,0.001463971,0.00004718901,0.00001382933,0.000003183944,0.000172323,0.00007273189,0.0006668754],"genre_scores_gemma":[0.9985248,0.0001072488,0.0004270694,0.00001868284,0.000002560209,0.000003018848,0.0001626198,0.00002260432,0.0007312985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002246809,"threshold_uncertainty_score":0.007516265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141756410388403,"score_gpt":0.3125956161608568,"score_spread":0.2984199751220166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}