{"id":"W4387135840","doi":"10.1136/ijgc-2023-esgo.886","title":"#1121 KEYNOTE-826: final overall survival results from a randomized, double-blind, phase 3 study of pembrolizumab + chemotherapy vs placebo + chemotherapy for first-line treatment of persistent, recurrent, or metastatic cervical cancer","year":2023,"lang":"en","type":"article","venue":"International Journal of Gynecological Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Pembrolizumab; Medicine; Carboplatin; Chemotherapy; Cervical cancer; Placebo; Internal medicine; Oncology; Interim analysis; Gemcitabine; Cancer; Cisplatin; Randomized controlled trial; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002498837,0.00162013,0.003289175,0.0005007772,0.0006452875,0.001080934,0.001200095,0.002231358,0.01370811],"category_scores_gemma":[0.001829104,0.000722761,0.002495639,0.0004091017,0.001133631,0.001149797,0.0004711079,0.003883012,0.001851096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007047229,"about_ca_system_score_gemma":0.001302039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009593126,"about_ca_topic_score_gemma":0.002325337,"domain_scores_codex":[0.99928,0.0004085716,0.00004530204,0.0001164974,0.00004977402,0.00009989844],"domain_scores_gemma":[0.9989027,0.0003568481,0.0002314829,0.00009649064,0.00007427787,0.0003381723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9769956,0.004658964,0.0002142966,0.0005060749,0.0007817078,0.00001975987,0.00002187318,0.0002293006,0.004211569,0.0000624731,0.001077748,0.01122075],"study_design_scores_gemma":[0.9460891,0.05120995,0.001122219,0.00002450875,0.00047667,0.00001467493,0.000008874821,0.0001467864,0.0004042959,0.00006357079,0.0004282119,0.00001113345],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701089,0.008401907,0.001302687,0.001424942,0.001255151,0.006225142,0.005699523,0.0003764838,0.005205305],"genre_scores_gemma":[0.9688219,0.004236471,0.003125417,0.002614758,0.001034134,0.006580977,0.00482669,0.0001159143,0.008643728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01370811,"threshold_uncertainty_score":0.0458582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1492172553272644,"score_gpt":0.4217730260514105,"score_spread":0.2725557707241461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}