{"id":"W4387139418","doi":"10.1101/2023.09.21.23295853","title":"A Phase 2, randomized, double-blind, placebo-controlled multi-center trial sub-study for the clinical effects of paridiprubart treatment in hospitalized critically ill patients with COVID-19 ARDS","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Respiratory Support and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Government of Canada","keywords":"ARDS; Medicine; Placebo; Internal medicine; Mechanical ventilation; Randomized controlled trial; Incidence (geometry); Lung; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00300806,0.002157648,0.003844627,0.0006844736,0.0006287121,0.001324546,0.001133098,0.002597199,0.007972231],"category_scores_gemma":[0.003068439,0.0009118523,0.001978314,0.000460811,0.001397114,0.001280689,0.0005143377,0.002636259,0.001173339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006350012,"about_ca_system_score_gemma":0.001514512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003920408,"about_ca_topic_score_gemma":0.000837238,"domain_scores_codex":[0.9988483,0.0005947919,0.00008889294,0.0002303925,0.00007653965,0.0001610049],"domain_scores_gemma":[0.998176,0.0005627441,0.000405982,0.000172354,0.0001793395,0.0005035758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9807732,0.009937784,0.0002990894,0.0003968059,0.0004384281,0.00002542213,0.00003486641,0.0001113612,0.002464969,0.00005669992,0.0002951798,0.005166142],"study_design_scores_gemma":[0.9553097,0.04368391,0.0004137808,0.0000096197,0.0001264632,0.00001170356,0.000007416244,0.0001081183,0.000161117,0.00003473635,0.0001289448,0.000004512435],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721243,0.004121573,0.001589068,0.0007218142,0.000778334,0.01703469,0.001388465,0.00019864,0.002043224],"genre_scores_gemma":[0.956962,0.002321635,0.004523878,0.001773869,0.0009887747,0.02885702,0.001600713,0.00003940141,0.002932761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007972231,"threshold_uncertainty_score":0.0266698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09344848556405069,"score_gpt":0.4144064226086477,"score_spread":0.320957937044597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}