{"id":"W4387142551","doi":"10.1016/j.cell.2023.08.037","title":"Human microglial state dynamics in Alzheimer’s disease progression","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":412,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada); University of British Columbia","funders":"National Human Genome Research Institute; National Institute on Aging; National Institutes of Health; Robert A. and Renee E. Belfer Family Foundation; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Cure Alzheimer's Fund; JPB Foundation; National Institute on Drug Abuse; Howard Hughes Medical Institute","keywords":"Biology; Microglia; Alzheimer's disease; Neuroscience; Dynamics (music); Disease; Inflammation; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009913072,0.0001063832,0.00007698304,0.000164882,0.0001378349,0.00006433672,0.0001610186,0.00002311802,0.00005512874],"category_scores_gemma":[0.00004247133,0.0001051496,0.00003505995,0.0003623124,0.00003252204,0.0001138102,0.0000757898,0.0001148037,0.000652823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002444429,"about_ca_system_score_gemma":0.00002967813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001364589,"about_ca_topic_score_gemma":0.00001377147,"domain_scores_codex":[0.9988889,0.0001178662,0.0002046409,0.0003443442,0.0002124125,0.0002318747],"domain_scores_gemma":[0.9995658,0.00003129901,0.00006353656,0.0002061777,0.00001188062,0.0001212518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001324335,0.00004925537,0.0001083614,0.000008015205,1.929226e-7,0.0002309378,0.00005516894,0.0002371609,0.9965095,0.001344252,0.0005680599,0.0008758784],"study_design_scores_gemma":[0.000363393,0.00002935727,0.0004510653,0.000006897871,0.000003205246,0.000001408096,0.000008815665,0.02303953,0.9741021,0.0009499288,0.0009261181,0.0001181323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970591,0.000008644257,0.00003664491,0.0004504955,0.0003694218,0.0003045715,0.00003118108,0.0002844724,0.001455458],"genre_scores_gemma":[0.9959421,0.00002266749,0.00003050097,0.000462366,0.00003777872,0.00002763857,0.00002282577,0.00002555989,0.003428531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02280237,"threshold_uncertainty_score":0.8390937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04354891155780605,"score_gpt":0.3051672845167821,"score_spread":0.2616183729589761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}