{"id":"W4387142583","doi":"10.1016/j.cell.2023.08.040","title":"Epigenomic dissection of Alzheimer’s disease pinpoints causal variants and reveals epigenome erosion","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute of Mental Health; Russian Science Foundation; Cure Alzheimer's Fund; National Institute on Aging; National Institutes of Health; National Science Foundation","keywords":"Epigenome; Biology; Epigenomics; Enhancer; Transcriptome; Genetics; Gene; Epigenetics; Computational biology; Gene regulatory network; Neuroscience; Transcription factor; Gene expression; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001747298,0.0001917645,0.0002382081,0.0008745986,0.0001464145,0.0002441655,0.0001464837,0.0001563493,0.001495118],"category_scores_gemma":[0.0004031664,0.0001197239,0.0001725204,0.0005222004,0.0001813892,0.0001472459,0.0002573296,0.0001696267,0.000151908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001343871,"about_ca_system_score_gemma":0.00009160024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001379854,"about_ca_topic_score_gemma":0.0038791,"domain_scores_codex":[0.9998919,0.00001276377,0.000004818714,0.00005255409,0.00001976851,0.00001822321],"domain_scores_gemma":[0.9997941,0.00005871507,0.00007448176,0.00002567365,0.0000213749,0.00002573076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004894487,0.00001900029,0.1638944,0.00008611575,0.000205077,0.0002341092,0.000314005,0.0005211303,0.8148846,0.0003768383,0.0001311738,0.01884413],"study_design_scores_gemma":[0.000006393289,0.00006670924,0.9540744,0.000008028102,0.00008268763,0.0005339868,0.0001567934,0.001330803,0.04205028,0.0006294645,0.001052804,0.000007523967],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927458,0.0007009364,0.004913581,0.00002914564,0.000002887791,0.000005369102,0.0008800739,0.00004906916,0.0006732013],"genre_scores_gemma":[0.9971094,0.0002224519,0.001868638,0.00001691877,0.000003299767,0.000006017933,0.0003997424,0.00001464737,0.0003588083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001495118,"threshold_uncertainty_score":0.005001664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899476275623367,"score_gpt":0.2644975392155078,"score_spread":0.2455027764592742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}