{"id":"W4387157790","doi":"10.1002/path.6195","title":"Hedgehog signalling in <i>Foxd1</i>+ embryonic kidney stromal progenitors controls nephron formation via <i>Cxcl12</i> and <i>Wnt5a</i>","year":2023,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Nephron; Biology; Hedgehog; Hedgehog signaling pathway; Kidney development; Kidney; Stromal cell; Sonic hedgehog; Cell biology; Embryonic stem cell; Progenitor cell; Internal medicine; Endocrinology; Stem cell; Cancer research; Signal transduction; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007589083,0.0001209233,0.000200295,0.00009052643,0.00007332095,0.00001218864,0.0001725522,0.0001610936,0.000002854912],"category_scores_gemma":[0.00005463868,0.00007924765,0.00007873569,0.0001538959,0.0001115838,0.00001310034,0.00005953311,0.0002669763,0.000006480253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002093484,"about_ca_system_score_gemma":0.00009316568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005000303,"about_ca_topic_score_gemma":0.000008968163,"domain_scores_codex":[0.9989498,0.0002181546,0.0003508014,0.0001071824,0.0001190673,0.0002549849],"domain_scores_gemma":[0.9994352,0.00003242987,0.0002639576,0.0001079141,0.00006919735,0.00009124083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003436396,0.00001661442,0.0005115592,0.00002061736,0.00003981021,0.00008948431,0.0002103259,0.00113091,0.9940586,0.000007972639,0.001746946,0.001823522],"study_design_scores_gemma":[0.01023717,0.004828315,0.005742431,0.0003409339,0.0003736288,0.01226594,0.001374865,0.002815319,0.9309214,0.00169397,0.02866478,0.0007412055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950009,0.002372051,0.00103643,0.001034052,0.0002935193,0.000141863,0.000005782157,0.000006449432,0.000108939],"genre_scores_gemma":[0.9961105,0.002766389,0.00006505496,0.0006532246,0.0002823067,0.000004906759,0.00001417204,0.00001409075,0.00008936643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06313716,"threshold_uncertainty_score":0.3231625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006298187837148777,"score_gpt":0.2254121806718305,"score_spread":0.2191139928346817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}