{"id":"W4387167010","doi":"10.1016/j.jbc.2023.105307","title":"Helicases in R-loop Formation and Resolution","year":2023,"lang":"en","type":"review","venue":"Journal of Biological Chemistry","topic":"Photosynthetic Processes and Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation; Leukemia and Lymphoma Society of Canada","keywords":"Loop (graph theory); Helicase; Biology; Chemistry; Computational biology; Genetics; Physics; Biophysics; Mathematics; Combinatorics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003717091,0.0001863811,0.0005987944,0.00004233055,0.00002336342,0.00001574285,0.0001851371,0.0005077362,0.000008431859],"category_scores_gemma":[0.0004344083,0.0001241276,0.000202669,0.0001098682,0.00004725508,0.000003853886,0.000119685,0.0002509442,0.000002734668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002765606,"about_ca_system_score_gemma":0.00009895195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.127628e-7,"about_ca_topic_score_gemma":7.41004e-7,"domain_scores_codex":[0.9989264,0.00004667462,0.0005820828,0.000186382,0.00009032135,0.0001681211],"domain_scores_gemma":[0.9992107,0.00003954761,0.0004943179,0.0001190881,0.00005637594,0.0000799706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001608387,0.0002141889,0.000005117457,0.0188939,0.0001798364,0.0001937429,0.00001642216,0.00000311862,0.3201184,0.00002235949,0.0005321502,0.6596599],"study_design_scores_gemma":[0.0002963501,0.0002958314,0.000001598206,0.004738472,0.0001032316,0.001630738,0.00004646996,0.000006583191,0.08779352,0.0002519518,0.9045492,0.00028607],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01204878,0.9875205,0.0001165186,0.00001456703,0.00005563187,0.0001031209,0.0000249451,0.000005445629,0.0001104633],"genre_scores_gemma":[0.001842881,0.9976334,0.00007529658,0.00001807976,0.0002331793,0.00001132341,0.00007304139,0.00001325783,0.00009954514],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.904017,"threshold_uncertainty_score":0.5061776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0727634328622396,"score_gpt":0.3323043587163891,"score_spread":0.2595409258541496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}