{"id":"W4387168380","doi":"10.7554/elife.87392","title":"The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureus","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; SickKids Foundation; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Svenska Läkaresällskapet; Stiftelsen Blanceflor Boncompagni Ludovisi, född Bildt; Hospital for Sick Children; Government of Ontario; Canada Research Chairs; Technische Universität Dresden; Canada Foundation for Innovation; Canadian Institutes of Health Research; Sick Kids Foundation","keywords":"Staphylococcus aureus; Innate immune system; Degranulation; Chemotaxis; NADPH oxidase; Microbiology; Immunology; Neutrophil extracellular traps; Biology; p38 mitogen-activated protein kinases; Antimicrobial peptides; Cell biology; Inflammation; Immune system; Chemistry; Reactive oxygen species; Kinase; Protein kinase A; Antimicrobial; Bacteria; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001114772,0.0003063932,0.000155632,0.0001241595,0.0001171473,0.0002814214,0.0001123144,0.0003014771,0.001050876],"category_scores_gemma":[0.00007725167,0.0000761615,0.0001729208,0.00006102555,0.0002039619,0.0002530287,0.0002309086,0.0004495442,0.0001697936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001620288,"about_ca_system_score_gemma":0.0001503935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002553585,"about_ca_topic_score_gemma":0.0006140188,"domain_scores_codex":[0.9999008,0.0000190629,0.000006998011,0.00001601812,0.00003033299,0.00002672676],"domain_scores_gemma":[0.9999462,0.000005286396,0.00001788907,0.000004745288,0.000007598802,0.00001825262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008130139,0.00001110446,0.0002382697,0.00002979793,0.000002815525,0.00005162698,0.000005936494,0.00002946345,0.9982635,0.00008289488,0.00005284815,0.001150393],"study_design_scores_gemma":[0.0000131398,0.0005213838,0.01164943,0.00001513891,0.0000140723,0.000507905,0.0000618021,0.0007303164,0.9821267,0.0001595454,0.004196004,0.000004699255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865202,0.006835794,0.003196775,0.0004378489,0.00007777861,0.00001830266,0.0002051902,0.00007433254,0.002633875],"genre_scores_gemma":[0.9927788,0.00224996,0.001501874,0.0001234903,0.00003768824,0.00001138903,0.0001449499,0.000006123992,0.003145648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001050876,"threshold_uncertainty_score":0.003515601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01747273845301874,"score_gpt":0.2468038859612562,"score_spread":0.2293311475082374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}