{"id":"W4387169311","doi":"10.1017/ash.2023.214","title":"Integrated efficacy analysis from phase 3 studies of investigational microbiome therapeutic, SER-109, in recurrent <i>Clostridioides difficile</i> infection","year":2023,"lang":"en","type":"article","venue":"Antimicrobial Stewardship & Healthcare Epidemiology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Clostridium difficile; Clostridioides; Internal medicine; Placebo; Regimen; Antibiotics; Clostridium difficile toxin A; Diarrhea; Clinical endpoint; Microbiome; Vancomycin; Fidaxomicin; Randomized controlled trial; Gastroenterology; Surgery; Microbiology; Biology; Pathology; Bioinformatics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00283996,0.0005451947,0.00255091,0.001845552,0.0002007974,0.0000137772,0.0002707909,0.0005692076,0.0001180986],"category_scores_gemma":[0.003716416,0.0004822222,0.0006959792,0.005832843,0.0007278369,0.00009269754,0.0002178578,0.001123235,0.00009240941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007248673,"about_ca_system_score_gemma":0.0008485118,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0125345,"about_ca_topic_score_gemma":0.002780547,"domain_scores_codex":[0.9930776,0.00200626,0.002258897,0.001110815,0.0003682633,0.001178114],"domain_scores_gemma":[0.9938961,0.003737479,0.0006105636,0.0006896823,0.0006776647,0.0003885355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003982819,0.002898234,0.4517545,0.001110237,0.004963047,0.0001492085,0.001736159,0.0008854571,0.4885769,0.0003946495,0.01120009,0.03234876],"study_design_scores_gemma":[0.01870199,0.006532473,0.5185028,0.002396814,0.002894448,0.00009435396,0.001537479,0.004323446,0.4307353,0.001495526,0.01106826,0.001717124],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772688,0.003877601,0.00008395212,0.01583047,0.0006138636,0.001060144,0.001040722,0.0002054864,0.00001903074],"genre_scores_gemma":[0.9848148,0.008487524,0.0003346581,0.001518747,0.0003401953,0.00006362937,0.004323479,0.00005462893,0.00006229706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06674836,"threshold_uncertainty_score":0.999763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.17662854859292,"score_gpt":0.4415952859989196,"score_spread":0.2649667374059996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}