{"id":"W4387169311","doi":"10.1017/ash.2023.214","title":"Integrated efficacy analysis from phase 3 studies of investigational microbiome therapeutic, SER-109, in recurrent <i>Clostridioides difficile</i> infection","year":2023,"lang":"en","type":"article","venue":"Antimicrobial Stewardship & Healthcare Epidemiology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Clostridium difficile; Clostridioides; Internal medicine; Placebo; Regimen; Antibiotics; Clostridium difficile toxin A; Diarrhea; Clinical endpoint; Microbiome; Vancomycin; Fidaxomicin; Randomized controlled trial; Gastroenterology; Surgery; Microbiology; Biology; Pathology; Bioinformatics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01244709,0.001585604,0.003062409,0.001029577,0.000624932,0.001684058,0.0008811951,0.001353817,0.00343938],"category_scores_gemma":[0.008863422,0.0006801673,0.006102563,0.001232837,0.0008557828,0.0008986198,0.0009073517,0.002037248,0.0003364995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002395667,"about_ca_system_score_gemma":0.005242013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004122398,"about_ca_topic_score_gemma":0.01073709,"domain_scores_codex":[0.9931632,0.004247996,0.0004553526,0.0005784886,0.0008795262,0.000675382],"domain_scores_gemma":[0.9896645,0.003154606,0.003526869,0.0007956902,0.00150958,0.001348783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.8935727,0.007227431,0.01120734,0.002173279,0.02001888,0.00006418117,0.0001868093,0.001675987,0.007699008,0.0001302587,0.00152348,0.05452059],"study_design_scores_gemma":[0.3986554,0.4411035,0.1039494,0.000495189,0.04346785,0.0002163707,0.0001653739,0.001166553,0.004946012,0.0003312108,0.005394633,0.0001084727],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682956,0.01052634,0.001995998,0.0004662526,0.0001422535,0.008017167,0.006716339,0.0001330928,0.003707023],"genre_scores_gemma":[0.9835464,0.002899191,0.002912572,0.000549748,0.0001507353,0.004480984,0.004573514,0.0000362861,0.0008506831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01244709,"threshold_uncertainty_score":0.06582731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.17662854859292,"score_gpt":0.4415952859989196,"score_spread":0.2649667374059996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}