{"id":"W4387186227","doi":"10.3390/ijms241914738","title":"How Does cGAS Avoid Sensing Self-DNA under Normal Physiological Conditions?","year":2023,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Saskatchewan","funders":"Priority Academic Program Development of Jiangsu Higher Education Institutions; National Natural Science Foundation of China","keywords":"DNA; Cell biology; Biology; Mitochondrial DNA; Innate immune system; Signal transducing adaptor protein; Cytosol; Genetics; Gene; Biochemistry; Signal transduction; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007470443,0.000305688,0.0008505444,0.0005337296,0.0001965514,0.0002483163,0.001243493,0.0003051954,0.0001412129],"category_scores_gemma":[0.000307247,0.0001784579,0.0007599189,0.0002556379,0.0005961859,0.0002502927,0.0002448426,0.0006449457,0.0002185203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001224165,"about_ca_system_score_gemma":0.000522601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005913215,"about_ca_topic_score_gemma":0.000001991913,"domain_scores_codex":[0.997714,0.0007015442,0.0006981236,0.0002935682,0.0002704048,0.0003223505],"domain_scores_gemma":[0.9981037,0.0003930546,0.0009265387,0.0001413669,0.0004008944,0.00003445552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004235371,0.00106537,0.000009200606,0.002197543,0.01971398,0.00428641,0.0008581833,0.0001171481,0.2107374,0.02077407,0.01575841,0.7240587],"study_design_scores_gemma":[0.0006043476,0.0005899493,0.00002779348,0.005957565,0.0004786534,0.005733621,0.0006465339,0.000005674794,0.009479773,0.001133012,0.9748175,0.0005255956],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005783433,0.9864069,0.0004318145,0.0008811765,0.005968497,0.0001624823,0.00005716458,0.00005659408,0.0002519653],"genre_scores_gemma":[0.0131259,0.984706,0.0003118381,0.0002478218,0.0002317334,0.000003349879,0.00005087249,0.00002526816,0.00129718],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9590591,"threshold_uncertainty_score":0.7277302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05234425457524487,"score_gpt":0.3493610789115453,"score_spread":0.2970168243363004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}