{"id":"W4387187881","doi":"10.3233/jad-230683","title":"A Metabolomics Analysis of a Novel Phenotype of Older Adults at Higher Risk of Dementia","year":2023,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Ontario Brain Institute; Western University","funders":"","keywords":"Cognitive decline; Dementia; Metabolomics; Cognition; Gait; Internal medicine; Medicine; Disease; Bioinformatics; Physiology; Biology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002559366,0.0004246561,0.00042761,0.0008266837,0.0002921361,0.0004860573,0.0001412798,0.0004906225,0.0012077],"category_scores_gemma":[0.0006353992,0.0001174283,0.0002596643,0.0005454531,0.000140986,0.000209564,0.0003527539,0.0003185263,0.0002213069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001527912,"about_ca_system_score_gemma":0.0001201122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001049619,"about_ca_topic_score_gemma":0.001269745,"domain_scores_codex":[0.9998934,0.00002000458,0.00001235021,0.00003671921,0.00002242108,0.00001504129],"domain_scores_gemma":[0.9997295,0.00003139374,0.0001151432,0.00002052183,0.00005760915,0.00004590926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003879673,0.0003072877,0.8724223,0.0001380811,0.000314694,0.0009524233,0.0002822397,0.0001658846,0.1032969,0.00006788912,0.0004329056,0.01773958],"study_design_scores_gemma":[0.00002249901,0.0006115041,0.9950729,0.000008312134,0.00006918325,0.001153139,0.0001305248,0.0002741352,0.002264178,0.00008545696,0.0003019363,0.000006265806],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982662,0.0003338822,0.00029142,0.0000537999,0.000005854637,0.0000211359,0.0006023777,0.00001140799,0.0004139916],"genre_scores_gemma":[0.9984993,0.0001203084,0.000556058,0.00006739014,0.000008806384,0.00001544824,0.0004361356,0.00000287999,0.0002936914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0012077,"threshold_uncertainty_score":0.004040182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01500871141244074,"score_gpt":0.2648756456085017,"score_spread":0.249866934196061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}