{"id":"W4387206699","doi":"10.1016/j.ijrobp.2023.06.1189","title":"Longitudinal Profiling of Tumor RNA Expression Signatures Reveal Key Biological Features Associated with Response to Neoadjuvant Stereotactic Body Radiation Therapy in High-Risk Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Genome British Columbia","funders":"","keywords":"Medicine; Prostate cancer; Immune system; Biopsy; Transcriptome; Prostatectomy; Prostate; Radiation therapy; Tumor microenvironment; Cancer research; Oncology; Cancer; Pathology; Internal medicine; Gene expression; Gene; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002681078,0.00009758867,0.0001938058,0.0003162629,0.0001853735,0.0004390998,0.000111473,0.0002065359,0.0006825195],"category_scores_gemma":[0.000762856,0.0001165483,0.0001449722,0.0003222371,0.0001632715,0.0002334524,0.000159152,0.0002868596,0.000171025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002011025,"about_ca_system_score_gemma":0.0002125164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007272495,"about_ca_topic_score_gemma":0.001748161,"domain_scores_codex":[0.9998648,0.00002806671,0.000007628082,0.00003927684,0.00002718594,0.00003296021],"domain_scores_gemma":[0.9995358,0.0001255706,0.0001992844,0.0000347731,0.00005636609,0.00004824389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002220566,0.0002381656,0.7542296,0.00005524453,0.0001652452,0.000125572,0.0002523103,0.0009879676,0.2105889,0.0001335379,0.00047887,0.03052398],"study_design_scores_gemma":[0.000006305655,0.0004367156,0.9865361,0.000005098076,0.00005490815,0.0001825617,0.000186872,0.001933836,0.009976158,0.0001038984,0.0005669401,0.00001053556],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986325,0.0003478778,0.0004394305,0.00004183774,0.000005205904,0.000005581707,0.0002524667,0.00001250402,0.000262476],"genre_scores_gemma":[0.9990514,0.00009110277,0.000179745,0.00002840873,0.000006750561,0.00001096497,0.0002796556,0.000004182889,0.0003477703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007272495,"threshold_uncertainty_score":0.002283275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02977765240054353,"score_gpt":0.3625320083308198,"score_spread":0.3327543559302762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}