{"id":"W4387207750","doi":"10.1016/j.ijrobp.2023.06.678","title":"Circulating Growth Differentiation Factor 15 as a Biomarker in Patients with Unresected Locally Advanced Non-Small Cell Lung Cancer Treated with Chemo-Radiotherapy with or without Metformin","year":2023,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"GDF15; Medicine; Metformin; Biomarker; Internal medicine; Chemotherapy; Oncology; Hazard ratio; Lung cancer; Cancer; Radiation therapy; Gastroenterology; Urology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002073535,0.0003424654,0.0006527698,0.0004871504,0.00007311284,0.0000306882,0.0002301783,0.0002935569,0.00008861237],"category_scores_gemma":[0.00007253915,0.0002030328,0.0001048005,0.0008695307,0.0001354513,0.0002965207,0.00002472032,0.0004682319,0.000003660301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001059912,"about_ca_system_score_gemma":0.0009164475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001218242,"about_ca_topic_score_gemma":0.00007778742,"domain_scores_codex":[0.9980219,0.0001379977,0.0006637095,0.0003504857,0.0004645716,0.0003613526],"domain_scores_gemma":[0.9972143,0.000216354,0.001126797,0.0001401593,0.001137108,0.0001653394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01124373,0.0005310897,0.9560457,0.00004079019,0.001581455,0.0001526853,0.0006684557,0.0007087017,0.01028414,0.00001334892,0.00008542352,0.01864444],"study_design_scores_gemma":[0.03733771,0.004323812,0.9284336,0.0005788639,0.000311643,0.0001236879,0.0001700381,0.02352824,0.004674923,0.000034148,0.0001333972,0.0003499492],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944097,0.0001139605,0.003702099,0.0003934661,0.0003176171,0.0007964399,0.00004143569,0.00006469263,0.0001605358],"genre_scores_gemma":[0.9969236,0.0003097613,0.001846998,0.000240287,0.0001939361,0.00004312556,0.0002499786,0.00006898677,0.0001233031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02761215,"threshold_uncertainty_score":0.8279438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01184315110325151,"score_gpt":0.3004924425616821,"score_spread":0.2886492914584306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}