{"id":"W4387207951","doi":"10.1016/j.ijrobp.2023.06.403","title":"Impact of Testosterone Recovery on Clinical Outcomes of Patients Treated with Salvage Radiotherapy and Androgen Suppression: A Secondary Analysis of the NRG/RTOG 0534 Sport Phase 3 Trial","year":2023,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; London Health Sciences Centre; McGill University Health Centre; Juravinski Cancer Centre; Université Laval","funders":"Genentech; Astellas Pharma; Foundation Medicine; MacroGenics; Puma Biotechnology; Sanofi; Exelixis; Plexxikon; RefleXion Medical; Varian Medical Systems; Boston Scientific Corporation; Celgene; Bristol-Myers Squibb; AstraZeneca; Amgen; Pfizer","keywords":"Medicine; Androgen deprivation therapy; Hazard ratio; Radiation therapy; Androgen suppression; Prostate cancer; Cumulative incidence; Proportional hazards model; Urology; Clinical endpoint; Testosterone (patch); Internal medicine; Oncology; Confidence interval; Clinical trial; Cohort; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002574796,0.001122213,0.00256599,0.0003457442,0.0003821476,0.001217403,0.0007675933,0.0007477104,0.003868773],"category_scores_gemma":[0.002455269,0.000254882,0.004489623,0.0005991691,0.0007797312,0.0009080894,0.0004980203,0.002774101,0.0005194081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007211033,"about_ca_system_score_gemma":0.001126454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001153163,"about_ca_topic_score_gemma":0.002624181,"domain_scores_codex":[0.9987314,0.000751665,0.00006797304,0.0001830261,0.0001014485,0.0001643948],"domain_scores_gemma":[0.9982904,0.0005082385,0.0005555678,0.0001745113,0.00008114084,0.0003902553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9489675,0.002700522,0.01064164,0.0004590055,0.007432877,0.00005770595,0.00005529268,0.001398518,0.001939657,0.0001818083,0.001601828,0.02456354],"study_design_scores_gemma":[0.5327181,0.2922694,0.1464877,0.0002145848,0.01671044,0.0003183446,0.0002155216,0.002929554,0.001925279,0.001923439,0.004178081,0.0001095795],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908063,0.004844752,0.0002782176,0.0004157274,0.0001885689,0.0002816561,0.001647994,0.00003533855,0.0015014],"genre_scores_gemma":[0.994813,0.0009106829,0.0002230874,0.0003822625,0.0002736415,0.0002422127,0.002128786,0.00001725665,0.001009247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003868773,"threshold_uncertainty_score":0.01361704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04164351739601194,"score_gpt":0.4274535760803052,"score_spread":0.3858100586842932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}