{"id":"W4387209890","doi":"10.1111/cas.15985","title":"Intratumoral administration of unconjugated Accum™ impairs the growth of pre‐established solid lymphoma tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Science","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Defence Research and Development Canada; Centre Hospitalier Universitaire Sainte-Justine; Université de Sherbrooke; Université de Montréal","funders":"Cancer Research Society","keywords":"Cancer research; Immune system; Programmed cell death; Immunogenic cell death; Endosome; Lymphoma; Pharmacology; Biology; CD8; Cell biology; Immunotherapy; Immunology; Apoptosis; Biochemistry; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001118476,0.0001039882,0.0002410245,0.0002244295,0.0001112294,0.00004348003,0.000507314,0.00003554123,0.0003488247],"category_scores_gemma":[0.0004106316,0.00007078378,0.00006221952,0.00346942,0.001390272,0.000257324,0.000108136,0.0001059094,0.00000583195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001595645,"about_ca_system_score_gemma":0.003067211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004959004,"about_ca_topic_score_gemma":0.00008976369,"domain_scores_codex":[0.9980913,0.00004355078,0.0003150631,0.0002936263,0.0008767497,0.0003797444],"domain_scores_gemma":[0.9987617,0.000102599,0.0001468204,0.0004350634,0.0004089397,0.0001449357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007606854,0.00008110369,0.01346683,0.000141595,0.00002210653,0.00002822478,0.001448389,0.00004354533,0.9722475,0.0004863533,0.001171845,0.01010183],"study_design_scores_gemma":[0.0007557563,0.0005748711,0.2253671,0.000122414,0.00001626675,0.00002735518,0.0004131905,0.00292707,0.7693262,0.0002677913,0.000121493,0.00008046985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960621,0.000104846,0.00001293287,0.001361882,0.0002268196,0.0004300478,0.00001668636,0.00004880022,0.001735878],"genre_scores_gemma":[0.9986077,0.0001124698,0.00003417776,0.00008760743,0.00008016083,0.00004736372,0.000006124064,0.00001159908,0.001012802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2119003,"threshold_uncertainty_score":0.5441102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03303650894573641,"score_gpt":0.3610230174798595,"score_spread":0.3279865085341231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}