{"id":"W4387226863","doi":"10.1016/j.oraloncology.2023.106580","title":"Loss of LRP1B expression drives acquired chemo and radio-resistance in HPV-positive head and neck cancer","year":2023,"lang":"en","type":"article","venue":"Oral Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; Western University","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Cancer research; Cisplatin; Radiation therapy; Oncology; Clonogenic assay; Head and neck cancer; Internal medicine; Cancer; Chemotherapy; Gene knockdown; In vivo; Cell culture; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001982884,0.00009458682,0.0002075876,0.0003118211,0.0002594438,0.0004559563,0.0002111827,0.0003399309,0.003375409],"category_scores_gemma":[0.0003607874,0.000171444,0.000181352,0.0002471511,0.000439815,0.0002286474,0.0002838352,0.0005084741,0.0005327683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003718839,"about_ca_system_score_gemma":0.0002324861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00138431,"about_ca_topic_score_gemma":0.001209609,"domain_scores_codex":[0.9997779,0.00004544866,0.00001456613,0.00003270876,0.00005736156,0.00007208364],"domain_scores_gemma":[0.9998665,0.00003648571,0.00003439077,0.00002133393,0.000014088,0.00002713514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007233984,0.0003082098,0.01245251,0.0000406132,0.00001761765,0.0004253867,0.0001398947,0.0001169893,0.9817909,0.000357578,0.0002044763,0.003422362],"study_design_scores_gemma":[0.0001159846,0.002535025,0.4047896,0.00002734527,0.00008278933,0.009457697,0.001459208,0.0037817,0.571413,0.0003724957,0.005941609,0.00002354353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990656,0.000159951,0.0001214354,0.00003025175,0.000005211332,0.000006607138,0.00008084985,0.000007292472,0.000522834],"genre_scores_gemma":[0.9991056,0.00008546282,0.0000662891,0.00001482331,0.000001392929,0.000005904109,0.00008580247,0.000005136461,0.0006294903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003375409,"threshold_uncertainty_score":0.01129186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02959430666647074,"score_gpt":0.361171574777958,"score_spread":0.3315772681114872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}