{"id":"W4387229227","doi":"10.1038/s41467-023-41860-z","title":"PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Stanford Maternal and Child Health Research Institute; Wellcome Trust; Agence Nationale de la Recherche; Institute of Molecular and Cell Biology; University of Oxford; National Institute of Diabetes and Digestive and Kidney Diseases; Stanford Diabetes Research Center; Duke-NUS Medical School; Lee Foundation; European Federation of Pharmaceutical Industries and Associations; European Commission; Japan Agency for Medical Research and Development","keywords":"PAX4; Biology; Beta cell; Diabetes mellitus; Internal medicine; Endocrinology; Gene; Genetics; Medicine; Transcription factor; Islet; Homeobox","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001261263,0.0002899805,0.0001448284,0.00028285,0.0001217847,0.0002425675,0.0001562639,0.0002872342,0.00330111],"category_scores_gemma":[0.0001503337,0.000101381,0.0001621466,0.0001704664,0.0002090144,0.0001344478,0.0002534672,0.0002842742,0.0002293182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001020958,"about_ca_system_score_gemma":0.0001158392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000301908,"about_ca_topic_score_gemma":0.0003193905,"domain_scores_codex":[0.9998933,0.00002883308,0.000009660701,0.00002567362,0.00002328268,0.00001928112],"domain_scores_gemma":[0.9999247,0.00001889704,0.00002657099,0.000007126316,0.000003001414,0.00001975581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005956804,0.00005781565,0.008068272,0.00002960543,0.00003853829,0.0004414402,0.00002574751,0.0001645213,0.9838191,0.0002151064,0.00009717563,0.006446998],"study_design_scores_gemma":[0.0001567038,0.001480906,0.1608908,0.00002550086,0.0002071408,0.008021137,0.000176022,0.00282915,0.8165351,0.0006597104,0.008993619,0.00002428667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975096,0.0004291743,0.0009154783,0.00008142149,0.00001374119,0.000008064787,0.0001802209,0.00003905938,0.0008231851],"genre_scores_gemma":[0.9979684,0.000281008,0.0005979899,0.00003109257,0.000005666835,0.000007896751,0.0001645476,0.00001342116,0.000929825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00330111,"threshold_uncertainty_score":0.01104331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01760295160072671,"score_gpt":0.2848968111072263,"score_spread":0.2672938595064996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}