{"id":"W4387230656","doi":"10.3390/ijms241914769","title":"Metabolomic Signatures of Alzheimer’s Disease Indicate Brain Region-Specific Neurodegenerative Progression","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; University of Lethbridge","keywords":"Metabolomics; Disease; Alzheimer's disease; Neuroscience; Neurodegeneration; Medicine; Biology; Bioinformatics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001589947,0.0003887417,0.0003130614,0.0008505778,0.0001488886,0.0002774936,0.0001084429,0.0002964635,0.001155879],"category_scores_gemma":[0.0001625646,0.0001283944,0.0002349247,0.0004003955,0.0001491813,0.0002025141,0.0002370736,0.0002227268,0.0001691775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001282688,"about_ca_system_score_gemma":0.0001111955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001217329,"about_ca_topic_score_gemma":0.002559764,"domain_scores_codex":[0.9999377,0.00001037013,0.000004048766,0.00002266414,0.00001018551,0.00001509536],"domain_scores_gemma":[0.9999307,0.00001219205,0.00002559049,0.000007172259,0.00001366671,0.00001051133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001511972,0.00006119177,0.02767138,0.0001354937,0.0002301506,0.0002987673,0.0001285442,0.0002115892,0.9540194,0.0001273353,0.0002445988,0.01535943],"study_design_scores_gemma":[0.00003311028,0.0006825164,0.8560255,0.00002228454,0.0003659883,0.002006712,0.0002739114,0.002266991,0.1355263,0.0008778008,0.001883124,0.00003580648],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919294,0.002675217,0.002990054,0.00008557687,0.00001745434,0.00002239883,0.001313071,0.00007659774,0.0008901969],"genre_scores_gemma":[0.9954638,0.0008305556,0.002356957,0.00005807883,0.00001304801,0.00001770646,0.000622222,0.000008816505,0.0006287739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001217329,"threshold_uncertainty_score":0.003866792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02829866055512386,"score_gpt":0.3215259758468197,"score_spread":0.2932273152916959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}