{"id":"W4387235643","doi":"10.1101/2023.09.30.560198","title":"Sex-Specific DNA Methylation and Gene Expression Changes in Mouse Placentas After Early Preimplantation Alcohol Exposure","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Centre de recherche du CHU Sainte-Justine; Génome Québec","keywords":"DNA methylation; Placenta; Biology; Andrology; Embryo; Pregnancy; Fetus; Methylation; Genomic imprinting; Embryogenesis; Context (archaeology); Differentially methylated regions; Gene expression; Internal medicine; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473564,0.0002398933,0.0002227944,0.0009218529,0.0001375978,0.0002350536,0.0001655793,0.0002424692,0.001243556],"category_scores_gemma":[0.0001113211,0.0002631144,0.0003202702,0.0003195355,0.0002148183,0.0001332175,0.000229189,0.0004368107,0.0002835385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002021628,"about_ca_system_score_gemma":0.0001262509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007621765,"about_ca_topic_score_gemma":0.0009642448,"domain_scores_codex":[0.9998451,0.0000143279,0.00001042281,0.00005428307,0.00004031761,0.00003556669],"domain_scores_gemma":[0.9998724,0.00001375758,0.00005225082,0.00001370398,0.00001706877,0.00003086002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001397086,0.000008288474,0.001295432,0.00001766632,0.000007381124,0.00004688358,0.00003316158,0.00001808811,0.9972905,0.00003106076,0.00001391019,0.001097976],"study_design_scores_gemma":[0.00001792075,0.0006371933,0.1533749,0.0000179775,0.00006350496,0.0006559238,0.0001563554,0.000540542,0.8417497,0.0001293836,0.002643237,0.0000133231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888298,0.003721769,0.004384918,0.00005035548,0.00002314194,0.0000365808,0.001574515,0.0001313513,0.001247648],"genre_scores_gemma":[0.9876037,0.002104084,0.003367906,0.00007079473,0.000009923159,0.00009789184,0.001509797,0.00006259953,0.005173367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001243556,"threshold_uncertainty_score":0.004160106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02076724789401622,"score_gpt":0.2396239779321426,"score_spread":0.2188567300381264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}