{"id":"W4387241265","doi":"10.1002/anie.202309744","title":"Stereoselective Synthesis of Sialyl Lewis<sup>a</sup> Antigen and the Effective Anticancer Activity of Its Bacteriophage Qβ Conjugate as an Anticancer Vaccine","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; College of Engineering, Michigan State University; National Cancer Institute; National Institutes of Health; University of Alberta; Michigan State University; Henry Ford Health System","keywords":"Keyhole limpet hemocyanin; Cancer immunotherapy; Conjugate; Antigen; Pancreatic cancer; Cancer; Antibody; Cancer research; Conjugate vaccine; Chemistry; Immunotherapy; Cytotoxicity; Immunology; Immunization; Virology; Medicine; Immune system; Biochemistry; In vitro; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001376957,0.0003449581,0.0001519679,0.0001669017,0.0001032539,0.0001424226,0.0001574996,0.0002219579,0.0006919282],"category_scores_gemma":[0.00008933366,0.00009887646,0.0002383603,0.0001775204,0.0001078822,0.0001393505,0.0001723989,0.0002893741,0.000402063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001690551,"about_ca_system_score_gemma":0.0002763241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003339123,"about_ca_topic_score_gemma":0.0002781155,"domain_scores_codex":[0.9999421,0.000009370907,0.000005143346,0.000009962947,0.00001246748,0.00002094373],"domain_scores_gemma":[0.9999624,0.000003398113,0.000008647793,0.000004468661,0.000007834163,0.00001306222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003381153,0.00002907396,0.00005178848,0.000031936,0.00000311011,0.00006060064,0.00001187812,0.0001726293,0.9973852,0.0003205236,0.00004842318,0.001851093],"study_design_scores_gemma":[0.00002148788,0.0004442009,0.0005401714,0.000003507105,0.000007792719,0.0001163982,0.000007732046,0.0008940735,0.9952761,0.00009953632,0.002582985,0.000006002178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775239,0.001052171,0.01655188,0.00009134788,0.00007923252,0.0002003313,0.0002904099,0.00008655261,0.0041241],"genre_scores_gemma":[0.986241,0.0008413895,0.009624046,0.0000520375,0.0000125673,0.00008971214,0.000277078,0.00002121454,0.002840988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006919282,"threshold_uncertainty_score":0.002314687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00968363179738022,"score_gpt":0.2907266581862197,"score_spread":0.2810430263888395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}