{"id":"W4387246264","doi":"10.1101/2023.09.30.23296350","title":"HIV-DRIVES: HIV Drug Resistance Identification, Variant Evaluation, & Surveillance Pipeline","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Human immunodeficiency virus (HIV); HIV drug resistance; Identification (biology); Pipeline (software); Virology; Drug resistance; Drug; Medicine; Computational biology; Computer science; Pharmacology; Biology; Viral load; Antiretroviral therapy; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003983575,0.001497602,0.001056813,0.001504187,0.0009236499,0.002827646,0.001529416,0.0006443832,0.02453984],"category_scores_gemma":[0.006570362,0.0009453745,0.001121738,0.001070057,0.0005118116,0.00125427,0.00258802,0.002036613,0.02913999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009693948,"about_ca_system_score_gemma":0.004016978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003499384,"about_ca_topic_score_gemma":0.004076484,"domain_scores_codex":[0.9984256,0.0002930505,0.000104697,0.0005049011,0.0005449277,0.0001268456],"domain_scores_gemma":[0.9978528,0.000735662,0.0002099812,0.0004420044,0.0005300361,0.000229495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001456099,0.0002112358,0.01554707,0.001953807,0.0004569392,0.0005982828,0.0007705512,0.009475666,0.0378757,0.0100836,0.691161,0.2304101],"study_design_scores_gemma":[0.0005803353,0.0003886516,0.0182057,0.0004023423,0.0002512049,0.001298063,0.0003674736,0.08979593,0.1018159,0.02600352,0.7605658,0.000325116],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"software","genre_gemma":"software","genre_scores_codex":[0.02019628,0.002040493,0.3028032,0.003061768,0.0005798875,0.001880695,0.2825036,0.3635119,0.02342238],"genre_scores_gemma":[0.08520597,0.001612951,0.493159,0.002883992,0.0003404874,0.002351714,0.3715103,0.0285839,0.01435175],"genre_candidate":"software","genre_consensus":"software","teacher_disagreement_score":0.02453984,"threshold_uncertainty_score":0.08209389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04308615488723088,"score_gpt":0.3154210557713319,"score_spread":0.272334900884101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}