{"id":"W4387264455","doi":"10.3390/biomedicines11102683","title":"Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells","year":2023,"lang":"en","type":"article","venue":"Biomedicines","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Facioscapulohumeral muscular dystrophy; Bromodomain; Biology; Skeletal muscle; BET inhibitor; Transcriptome; Gene expression; Regulation of gene expression; BRD4; Cell biology; Gene; Cancer research; Molecular biology; Epigenetics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005340303,0.0002204749,0.0002953247,0.0002371969,0.0001096519,0.00001831085,0.0002128186,0.0002662142,0.00002714105],"category_scores_gemma":[0.0001179175,0.0001880815,0.0001081205,0.0005260195,0.0001994832,0.0000121082,0.0001969861,0.0001511106,0.00004145956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002589734,"about_ca_system_score_gemma":0.00009935665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002350737,"about_ca_topic_score_gemma":0.00001463956,"domain_scores_codex":[0.998234,0.0001463659,0.000482592,0.000551207,0.0002449702,0.000340874],"domain_scores_gemma":[0.9992087,0.00003202703,0.0001590344,0.0003637042,0.00008979416,0.0001467029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003772827,0.0001195347,0.005650147,0.00003526008,0.00001648295,0.00001486675,0.00004346245,0.000002964249,0.9174421,0.000002545708,0.07542435,0.001210585],"study_design_scores_gemma":[0.001251884,0.0004034073,0.03746862,0.00006539851,0.000007641599,0.000001281635,0.00008825991,0.00001584495,0.8303907,0.00002851625,0.1300504,0.0002280383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996262,0.000642869,0.0001316143,0.0003222732,0.0007581227,0.0004323918,0.00006175797,0.00008688452,0.00130213],"genre_scores_gemma":[0.9895607,0.0005230469,0.001306427,0.0006616201,0.001500533,0.00008645377,0.001525098,0.0000492787,0.004786847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0870514,"threshold_uncertainty_score":0.7669742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02468307031653192,"score_gpt":0.3093755581840328,"score_spread":0.2846924878675008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}