{"id":"W4387264455","doi":"10.3390/biomedicines11102683","title":"Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells","year":2023,"lang":"en","type":"article","venue":"Biomedicines","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Facioscapulohumeral muscular dystrophy; Bromodomain; Biology; Skeletal muscle; BET inhibitor; Transcriptome; Gene expression; Regulation of gene expression; BRD4; Cell biology; Gene; Cancer research; Molecular biology; Epigenetics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008507551,0.0002291239,0.0002435285,0.000181978,0.000138062,0.0001940758,0.0001211492,0.0001672466,0.001853169],"category_scores_gemma":[0.00009161011,0.00007437033,0.0001618684,0.0001458111,0.0001508266,0.00008908432,0.00008256398,0.0003767081,0.0002703618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001579565,"about_ca_system_score_gemma":0.0002183896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005734878,"about_ca_topic_score_gemma":0.00193625,"domain_scores_codex":[0.9999311,0.00001216358,0.000008632896,0.00001616004,0.00001951952,0.00001249259],"domain_scores_gemma":[0.9999592,0.00001190987,0.000007681396,0.000003608144,0.000005333336,0.00001231392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003988713,0.00004554216,0.0002396874,0.0000525306,0.000006951774,0.00003432994,0.00001061937,0.00006799391,0.9965754,0.00003166323,0.00005568045,0.002480663],"study_design_scores_gemma":[0.00009329275,0.001847699,0.005953443,0.000005265732,0.00002840542,0.0002533572,0.00003469171,0.0004654741,0.9871787,0.00003184654,0.004103836,0.000004061707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936177,0.002937111,0.001250168,0.00008850962,0.00004331348,0.00006079976,0.0006740284,0.00005852199,0.001269851],"genre_scores_gemma":[0.9914226,0.001614873,0.002009218,0.00006676031,0.00001174063,0.00007409791,0.001279305,0.00001289706,0.003508434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001853169,"threshold_uncertainty_score":0.006199479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02468307031653192,"score_gpt":0.3093755581840328,"score_spread":0.2846924878675008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}