{"id":"W4387267748","doi":"10.3390/cells12192395","title":"Enhancing Antisense Oligonucleotide-Based Therapeutic Delivery with DG9, a Versatile Cell-Penetrating Peptide","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Muscular Dystrophy Canada; University of Alberta; Canadian Institutes of Health Research; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Morpholino; Oligonucleotide; Context (archaeology); Spinal muscular atrophy; Exon skipping; Antisense therapy; Cell-penetrating peptide; Chemistry; Computational biology; Medicine; Pharmacology; Cell; Biology; Gene knockdown; RNA; Biochemistry; RNA splicing; Pathology; Apoptosis; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001785808,0.0006617794,0.0004990106,0.001063268,0.0001288593,0.0004418757,0.0003645617,0.0005738974,0.00112291],"category_scores_gemma":[0.0001579478,0.0001891158,0.0002243411,0.0008593816,0.000226766,0.000602124,0.0003187411,0.0008568488,0.0009938442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003476435,"about_ca_system_score_gemma":0.0003735537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005551446,"about_ca_topic_score_gemma":0.0008692237,"domain_scores_codex":[0.9999295,0.000008565087,0.000006676849,0.00001531909,0.00003022021,0.00000966458],"domain_scores_gemma":[0.9999592,0.00001547381,0.000008791892,0.000001231137,0.00001012482,0.000005056363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006248306,0.00009904539,0.0001150545,0.01015821,0.00004876954,0.0002679901,0.0000624217,0.0006277381,0.04188333,0.006188469,0.01191758,0.9285689],"study_design_scores_gemma":[0.00001453859,0.0002136526,0.0005692508,0.0008791213,0.00006527535,0.00169631,0.00003589287,0.0002457902,0.01502961,0.001003218,0.9802245,0.00002273536],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000839809,0.9956957,0.0006963393,0.0001226835,0.0001549605,0.000008977598,0.00002215992,0.00002326199,0.002436019],"genre_scores_gemma":[0.003669905,0.9932317,0.0006671399,0.0001476137,0.00007060396,0.00001466339,0.00004888765,0.000003612935,0.002145983],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00112291,"threshold_uncertainty_score":0.003756523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03127853467963868,"score_gpt":0.2791044464362774,"score_spread":0.2478259117566387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}