{"id":"W4387267748","doi":"10.3390/cells12192395","title":"Enhancing Antisense Oligonucleotide-Based Therapeutic Delivery with DG9, a Versatile Cell-Penetrating Peptide","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Muscular Dystrophy Canada; University of Alberta; Canadian Institutes of Health Research; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Morpholino; Oligonucleotide; Context (archaeology); Spinal muscular atrophy; Exon skipping; Antisense therapy; Cell-penetrating peptide; Chemistry; Computational biology; Medicine; Pharmacology; Cell; Biology; Gene knockdown; RNA; Biochemistry; RNA splicing; Pathology; Apoptosis; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002027156,0.0005719128,0.0008234244,0.0001397735,0.0001246869,0.00008978935,0.0004160832,0.0003836177,0.00005355635],"category_scores_gemma":[0.00001327364,0.0004718369,0.0004493711,0.0002307816,0.00008308336,0.000005345001,0.0001173681,0.0002933229,0.0005534798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004092545,"about_ca_system_score_gemma":0.0005803949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004376276,"about_ca_topic_score_gemma":0.0000892316,"domain_scores_codex":[0.9978207,0.0001536787,0.0005225614,0.0007835371,0.000208424,0.0005110566],"domain_scores_gemma":[0.9986387,0.00008893328,0.0003515272,0.0006957123,0.0001033845,0.0001217499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002052725,0.0003280136,0.0000393491,0.03245221,0.001656118,0.0006114027,0.0002129398,0.0004785607,0.5417679,0.000006071295,0.01090922,0.4113329],"study_design_scores_gemma":[0.0005727063,0.0009173041,0.00000547675,0.008858952,0.000975398,0.00003327605,0.0001581546,0.00005115086,0.2708583,0.000003125301,0.7162266,0.001339566],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01323829,0.9840596,0.0003660102,0.000004614407,0.0003390455,0.0006659255,0.00007878966,0.00006609043,0.001181577],"genre_scores_gemma":[0.007036785,0.9887897,0.0004407361,0.0001883877,0.000332556,0.00007088426,0.0004020693,0.0001745266,0.002564296],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7053174,"threshold_uncertainty_score":0.9997733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03127853467963868,"score_gpt":0.2791044464362774,"score_spread":0.2478259117566387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}