{"id":"W4387267794","doi":"10.1038/s43018-023-00634-8","title":"Immunotargeting of a recurrent AML-specific neoantigen","year":2023,"lang":"en","type":"article","venue":"Nature Cancer","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Myeloid leukemia; Human leukocyte antigen; Medicine; Immunology; Myeloid; Cancer research; Oncology; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000313807,0.0001057395,0.0002503425,0.0001817304,0.00004065829,0.0000086867,0.0001265634,0.0001971528,0.006428238],"category_scores_gemma":[0.00007526373,0.00008797117,0.0001272168,0.0008430168,0.00005716443,0.00002652091,0.00005741628,0.0008085993,0.00008709339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001489386,"about_ca_system_score_gemma":0.0001460545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003071058,"about_ca_topic_score_gemma":0.000008753241,"domain_scores_codex":[0.9987583,0.00003208022,0.0001897016,0.000233206,0.0004795126,0.0003072286],"domain_scores_gemma":[0.9992633,0.00007439306,0.00005760758,0.0003167634,0.0002106811,0.00007724571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000700351,0.00004944293,0.00727441,0.0001860318,0.0001396716,0.0000475305,0.0006285516,0.000009096817,0.6879974,0.000164052,0.07773242,0.225071],"study_design_scores_gemma":[0.001129092,0.0001261971,0.04027196,0.000298838,0.0000200297,0.000007315648,0.0001358566,0.0001112185,0.08709889,0.00006875161,0.8706106,0.000121265],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9390778,0.04867645,0.00000432353,0.002320658,0.001235579,0.0004746311,0.00003208043,0.0001282611,0.008050209],"genre_scores_gemma":[0.97078,0.01313074,0.0001428881,0.0002541088,0.000895993,0.00005916377,0.00005367864,0.00005146334,0.01463203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7928782,"threshold_uncertainty_score":0.99448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03267180719695787,"score_gpt":0.373176615773337,"score_spread":0.3405048085763791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}