{"id":"W4387270164","doi":"10.1161/atvb.43.suppl_1.336","title":"Abstract 336: Endothelial Cells Communicate with Surrounding Vascular Cells Via Bidirectional and Polarized Secretion of Extracellular Vesicular Cargo: Implications for Atherosclerotic Plaque Development","year":2023,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; St. Michael's Hospital; Toronto General Hospital","funders":"","keywords":"Cell biology; Microvesicles; Secretion; Cell; Extracellular vesicle; Exosome; Western blot; Extracellular; Chemistry; Vascular smooth muscle; Intracellular; microRNA; Biology; Biochemistry; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003901234,0.0004202011,0.0003998127,0.0002079687,0.0002397646,0.001060077,0.0002457673,0.0005469978,0.004966297],"category_scores_gemma":[0.0002913503,0.0001578809,0.000342514,0.0002262356,0.0002671222,0.0005462393,0.0003268515,0.0006507179,0.001850686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002133804,"about_ca_system_score_gemma":0.0001983222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001849917,"about_ca_topic_score_gemma":0.0001458933,"domain_scores_codex":[0.9996353,0.00006613905,0.00003267202,0.0001007445,0.0001215647,0.00004350679],"domain_scores_gemma":[0.9997157,0.00004755131,0.00008549634,0.00002008137,0.00009001246,0.0000412223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004059929,0.00003574651,0.002065888,0.0004393218,0.00002747241,0.0002514063,0.00007340928,0.0001415179,0.9871718,0.0005124381,0.0006967028,0.008178346],"study_design_scores_gemma":[0.00005844087,0.0007085397,0.05114271,0.000140086,0.0001449199,0.002107366,0.0003870507,0.003359721,0.917067,0.001296788,0.02355106,0.0000363084],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9413707,0.0173632,0.02608082,0.001987293,0.000561901,0.0000582512,0.00389135,0.0004028143,0.008283635],"genre_scores_gemma":[0.9734012,0.006165446,0.005374772,0.0004989048,0.0002119103,0.00005644756,0.002748365,0.00009729834,0.01144568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004966297,"threshold_uncertainty_score":0.0166139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03226056877495168,"score_gpt":0.2702658446183941,"score_spread":0.2380052758434425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}