{"id":"W4387270370","doi":"10.1161/atvb.43.suppl_1.320","title":"Abstract 320: Metabolic Basis Of Vascular Smooth Muscle Cell Phenotypic Switching And Atherosclerosis","year":2023,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"","keywords":"Mitochondrial fission; Vascular smooth muscle; Transdifferentiation; Phenotype; Cell biology; Downregulation and upregulation; Biology; Mitochondrion; DNM1L; Gene knockdown; Bioenergetics; Phenotypic switching; Endocrinology; Apoptosis; Biochemistry; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001548224,0.0003527095,0.0001582327,0.0002225494,0.0001313918,0.0002503202,0.000186604,0.000293618,0.002248081],"category_scores_gemma":[0.00009175768,0.00008431905,0.0001478488,0.0001973987,0.0001985987,0.0002011541,0.0001792575,0.0004690053,0.0004517783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002149511,"about_ca_system_score_gemma":0.0001200588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001662016,"about_ca_topic_score_gemma":0.0001774654,"domain_scores_codex":[0.9999357,0.00001144052,0.000006414468,0.0000161169,0.00001887109,0.00001144605],"domain_scores_gemma":[0.9999127,0.00001083644,0.00002900123,0.000007156402,0.00001609361,0.00002425833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003214164,0.00003624404,0.0007241787,0.0001299321,0.000007476855,0.0001407134,0.00001197373,0.00006037053,0.9944824,0.0002846058,0.0001246803,0.003676142],"study_design_scores_gemma":[0.00007229174,0.0009043426,0.05872536,0.00004547393,0.00007314801,0.001679394,0.0000704564,0.001748485,0.9270741,0.0009482867,0.008648052,0.00001065118],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816303,0.008024771,0.003824732,0.0007328671,0.0001185632,0.00003965229,0.0008416052,0.00008969531,0.004697772],"genre_scores_gemma":[0.9840343,0.005505413,0.002419503,0.0001378772,0.0001201291,0.00004562579,0.001236672,0.00001783442,0.006482729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002248081,"threshold_uncertainty_score":0.007520556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635195134853412,"score_gpt":0.2569681344349652,"score_spread":0.2306161830864311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}