{"id":"W4387270379","doi":"10.1161/atvb.43.suppl_1.288","title":"Abstract 288: Development Of A Phenotypic Screen With 56 Marfan Syndrome Patient-derived Fibroblasts","year":2023,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Fibrillin; Marfan syndrome; Extracellular matrix; Fibroblast; Elastin; Connective tissue; Phenotype; Medicine; Pathology; Cell biology; Biology; Cell culture; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003169,0.0004614611,0.0004173876,0.0004639229,0.0002913064,0.0003151514,0.0002730578,0.0004111246,0.002530199],"category_scores_gemma":[0.0004691845,0.0001436988,0.0004117076,0.0003291311,0.0001061438,0.00009518499,0.0003413894,0.0003231708,0.001025737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001341269,"about_ca_system_score_gemma":0.0002419798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007760793,"about_ca_topic_score_gemma":0.001345798,"domain_scores_codex":[0.9995732,0.00007343334,0.0000486995,0.00009234784,0.0001622882,0.00005006697],"domain_scores_gemma":[0.9998289,0.0000508645,0.00001606295,0.00002987619,0.00004374965,0.00003043506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002010958,0.0001794255,0.003916058,0.00004542717,0.00001361358,0.0009274039,0.00005678505,0.0001086277,0.9861363,0.00004805008,0.0002274805,0.008139648],"study_design_scores_gemma":[0.0002126669,0.003540561,0.06210132,0.00004457825,0.0002205957,0.0150197,0.0003085128,0.002087266,0.8991043,0.0001294523,0.01719685,0.00003425256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832579,0.0007844356,0.007258629,0.0001923308,0.00004613634,0.0005866535,0.004119107,0.0001220635,0.003632736],"genre_scores_gemma":[0.9585859,0.001533813,0.01847796,0.0002628127,0.00003502074,0.0006968474,0.01184267,0.0000808125,0.008484281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002530199,"threshold_uncertainty_score":0.008464336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03043022728901086,"score_gpt":0.2789237869334054,"score_spread":0.2484935596443945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}