{"id":"W4387296095","doi":"10.1186/s13148-023-01571-0","title":"Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells","year":2023,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Ministerio de Universidades; Common Fund; National Institute of Environmental Health Sciences; National Cancer Institute; National Human Genome Research Institute; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; NIH Office of the Director; University of California, San Francisco; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Universidad de La Laguna; Ministerio de Ciencia e Innovación; New York Genome Center; American Asthma Foundation; National Institute on Drug Abuse; National Institute on Minority Health and Health Disparities; Tobacco-Related Disease Research Program","keywords":"dNaM; DNA methylation; Epigenomics; Epigenome; Bronchodilator; CpG site; Asthma; Epigenetics; Medicine; H3K4me3; Salbutamol; Biology; Immunology; Promoter; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001016436,0.0002835007,0.0006864078,0.0002734069,0.00007130425,0.00001861557,0.0001786074,0.0002481624,0.000157273],"category_scores_gemma":[0.0006206962,0.000223883,0.0003754366,0.0004691631,0.0001546236,0.00001862913,0.0001179617,0.0002222584,0.005973364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001628381,"about_ca_system_score_gemma":0.000535289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002609055,"about_ca_topic_score_gemma":0.00005441321,"domain_scores_codex":[0.996966,0.0004799801,0.001053678,0.0006218252,0.0002849696,0.0005935131],"domain_scores_gemma":[0.9972644,0.001102236,0.0001021648,0.0006664057,0.0000684055,0.0007963286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02006024,0.004732721,0.18876,0.0001297498,0.0002642569,0.00446785,0.001386933,0.005164728,0.1315701,0.00002910689,0.009452067,0.6339823],"study_design_scores_gemma":[0.004150739,0.006565192,0.6029131,0.00008674814,0.00007369459,0.000004951487,0.0001360658,0.0006168695,0.01546938,0.00007523759,0.3695884,0.0003196454],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950891,0.0002420875,0.0001383878,0.00250698,0.0006923291,0.0009382131,0.0001138606,0.0001279715,0.0001511346],"genre_scores_gemma":[0.9906321,0.0008561271,0.0007838014,0.002168939,0.0007200839,0.00008850718,0.00002262356,0.00007390453,0.004653945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6336627,"threshold_uncertainty_score":0.9948006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0415960035546869,"score_gpt":0.3642143311157816,"score_spread":0.3226183275610947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}