{"id":"W4387296095","doi":"10.1186/s13148-023-01571-0","title":"Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells","year":2023,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Ministerio de Universidades; Common Fund; National Institute of Environmental Health Sciences; National Cancer Institute; National Human Genome Research Institute; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; NIH Office of the Director; University of California, San Francisco; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Universidad de La Laguna; Ministerio de Ciencia e Innovación; New York Genome Center; American Asthma Foundation; National Institute on Drug Abuse; National Institute on Minority Health and Health Disparities; Tobacco-Related Disease Research Program","keywords":"dNaM; DNA methylation; Epigenomics; Epigenome; Bronchodilator; CpG site; Asthma; Epigenetics; Medicine; H3K4me3; Salbutamol; Biology; Immunology; Promoter; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001476127,0.0001195557,0.0002455829,0.0002869627,0.0001719132,0.0002157537,0.0001390593,0.0001722262,0.001630425],"category_scores_gemma":[0.0002633957,0.00008297021,0.0001871607,0.0004115308,0.0001229731,0.00005678312,0.0002226706,0.0001564006,0.0001851389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000219933,"about_ca_system_score_gemma":0.0001768815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003312434,"about_ca_topic_score_gemma":0.004352309,"domain_scores_codex":[0.9998323,0.00003217508,0.00000946163,0.00005806828,0.00004143732,0.00002661289],"domain_scores_gemma":[0.9998394,0.00004155622,0.00003914617,0.00002842826,0.00003524847,0.00001615289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004956105,0.00002227172,0.04018558,0.0000753787,0.00008460745,0.00007204144,0.00008371853,0.0002125683,0.9544324,0.00003485949,0.0001565183,0.004144398],"study_design_scores_gemma":[0.000020552,0.0002709112,0.8181517,0.000007295269,0.0001213348,0.0003380517,0.0001867759,0.00117368,0.1777493,0.00005283935,0.001919296,0.000008246969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950871,0.0007321583,0.000946706,0.00005281531,0.00000739879,0.00002059958,0.00256245,0.00002862201,0.0005622866],"genre_scores_gemma":[0.9956463,0.000264351,0.0008064118,0.00006245026,0.000004243609,0.00004836351,0.00242576,0.000009147612,0.0007328884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003312434,"threshold_uncertainty_score":0.006586313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0415960035546869,"score_gpt":0.3642143311157816,"score_spread":0.3226183275610947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}