{"id":"W4387296735","doi":"10.1158/1078-0432.ccr-23-1735","title":"Intratumoral Delivery of Chimeric Antigen Receptor T Cells Targeting CD133 Effectively Treats Brain Metastases","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canada Foundation for Innovation; Mitacs; Canada Research Chairs","keywords":"Chimeric antigen receptor; Medicine; Antigen; Population; Cancer research; Cancer stem cell; Metastasis; Immunotherapy; Immunology; Oncology; Cancer; Internal medicine; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002311875,0.0002474074,0.0002296284,0.0001861936,0.0001221873,0.0003368325,0.0002374821,0.0005759071,0.0006306355],"category_scores_gemma":[0.0001748972,0.00006433752,0.0001594299,0.0001421911,0.0006028133,0.0002498292,0.0001487471,0.001421672,0.0002987244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004358058,"about_ca_system_score_gemma":0.0004721161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005053807,"about_ca_topic_score_gemma":0.001316973,"domain_scores_codex":[0.9999241,0.00001742029,0.000003344539,0.00001543362,0.00002379462,0.00001594345],"domain_scores_gemma":[0.999936,0.0000263012,0.00001034568,0.000004267924,0.00001150076,0.000011629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001735012,0.0005953649,0.0007498328,0.0008414338,0.00006537298,0.001091844,0.000132177,0.001120694,0.7497582,0.00534761,0.04197506,0.1965874],"study_design_scores_gemma":[0.001450379,0.005856609,0.00668153,0.0002062283,0.0002202976,0.003544333,0.0002238318,0.003941586,0.6846535,0.002122103,0.2910438,0.000055785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.727414,0.1549716,0.01581514,0.05758972,0.006602109,0.0004358446,0.000466819,0.001287803,0.03541705],"genre_scores_gemma":[0.8972518,0.06719448,0.004800412,0.01070928,0.003113498,0.0002014685,0.0002486326,0.0001254445,0.01635494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006306355,"threshold_uncertainty_score":0.003161967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2065905562802892,"score_gpt":0.5196007385964388,"score_spread":0.3130101823161496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}