{"id":"W4387296964","doi":"10.1002/ana.26804","title":"Association of Chronic Pain with Biomarkers of Neurodegeneration, Microglial Activation, and Inflammation in <scp>Cerebrospinal Fluid</scp> and Impaired Cognitive Function","year":2023,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Neurodegeneration; Chronic pain; Medicine; Cerebrospinal fluid; Internal medicine; Cognitive decline; Alzheimer's disease; Dementia; Disease; Psychology; Physical therapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009822451,0.0003564208,0.0004207629,0.0006863405,0.0003300769,0.0007978103,0.0002979409,0.0004820611,0.001361881],"category_scores_gemma":[0.003368996,0.0001432857,0.000434976,0.0007625881,0.0002669674,0.0003638144,0.0004496428,0.0004108497,0.0001078657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002456701,"about_ca_system_score_gemma":0.0003039791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004504392,"about_ca_topic_score_gemma":0.006360457,"domain_scores_codex":[0.9994024,0.0001530303,0.00009614402,0.0001214296,0.0001280661,0.00009887814],"domain_scores_gemma":[0.9970221,0.000445431,0.001919946,0.0001040971,0.0003023005,0.0002061994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003679949,0.0000531285,0.9971443,0.00002913279,0.0001643999,0.000101861,0.00003202151,0.00004497134,0.0004525923,0.0000128944,0.0000548156,0.00154198],"study_design_scores_gemma":[0.00000714448,0.0001163618,0.9993396,0.000009390034,0.00002817358,0.0002385532,0.00003259987,0.0001133625,0.00005529745,0.00001856711,0.00003877859,0.000001990654],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987229,0.0005173689,0.00008687825,0.00004451748,0.000004651848,0.000009159162,0.0004226411,0.000002307965,0.0001895022],"genre_scores_gemma":[0.9990817,0.0001777209,0.0001207433,0.00002210858,0.00001701028,0.000008671321,0.0004482501,6.857608e-7,0.0001231776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004504392,"threshold_uncertainty_score":0.008956313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966235382414441,"score_gpt":0.2634234757135762,"score_spread":0.2437611218894318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}